Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3–11 years) and adults. Antibody responses against spike protein were high in children and seroconversion boosted re...

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Detalles Bibliográficos
Autores principales: Dowell, Alexander C., Butler, Megan S., Jinks, Elizabeth, Tut, Gokhan, Lancaster, Tara, Sylla, Panagiota, Begum, Jusnara, Bruton, Rachel, Pearce, Hayden, Verma, Kriti, Logan, Nicola, Tyson, Grace, Spalkova, Eliska, Margielewska-Davies, Sandra, Taylor, Graham S., Syrimi, Eleni, Baawuah, Frances, Beckmann, Joanne, Okike, Ifeanyichukwu O., Ahmad, Shazaad, Garstang, Joanna, Brent, Andrew J., Brent, Bernadette, Ireland, Georgina, Aiano, Felicity, Amin-Chowdhury, Zahin, Jones, Samuel, Borrow, Ray, Linley, Ezra, Wright, John, Azad, Rafaq, Waiblinger, Dagmar, Davis, Chris, Thomson, Emma C., Palmarini, Massimo, Willett, Brian J., Barclay, Wendy S., Poh, John, Amirthalingam, Gayatri, Brown, Kevin E., Ramsay, Mary E., Zuo, Jianmin, Moss, Paul, Ladhani, Shamez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709786/
https://www.ncbi.nlm.nih.gov/pubmed/34937928
http://dx.doi.org/10.1038/s41590-021-01089-8

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