An immunodominant NP(105–113)-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

NP(105–113)-B*07:02-specific CD8(+) T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP(105–113)-B*07:02-specific T cell clones and single-cell sequencing were performed concurrentl...

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Detalles Bibliográficos
Autores principales: Peng, Yanchun, Felce, Suet Ling, Dong, Danning, Penkava, Frank, Mentzer, Alexander J., Yao, Xuan, Liu, Guihai, Yin, Zixi, Chen, Ji-Li, Lu, Yongxu, Wellington, Dannielle, Wing, Peter A. C., Dominey-Foy, Delaney C. C., Jin, Chen, Wang, Wenbo, Hamid, Megat Abd, Fernandes, Ricardo A., Wang, Beibei, Fries, Anastasia, Zhuang, Xiaodong, Ashley, Neil, Rostron, Timothy, Waugh, Craig, Sopp, Paul, Hublitz, Philip, Beveridge, Ryan, Tan, Tiong Kit, Dold, Christina, Kwok, Andrew J., Rich-Griffin, Charlotte, Dejnirattisa, Wanwisa, Liu, Chang, Kurupati, Prathiba, Nassiri, Isar, Watson, Robert A., Tong, Orion, Taylor, Chelsea A., Kumar Sharma, Piyush, Sun, Bo, Curion, Fabiola, Revale, Santiago, Garner, Lucy C., Jansen, Kathrin, Ferreira, Ricardo C., Attar, Moustafa, Fry, Jeremy W., Russell, Rebecca A., Stauss, Hans J., James, William, Townsend, Alain, Ho, Ling-Pei, Klenerman, Paul, Mongkolsapaya, Juthathip, Screaton, Gavin R., Dendrou, Calliope, Sansom, Stephen N., Bashford-Rogers, Rachael, Chain, Benny, Smith, Geoffrey L., McKeating, Jane A., Fairfax, Benjamin P., Bowness, Paul, McMichael, Andrew J., Ogg, Graham, Knight, Julian C., Dong, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709787/
https://www.ncbi.nlm.nih.gov/pubmed/34853448
http://dx.doi.org/10.1038/s41590-021-01084-z

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