Cargando…

Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers

PURPOSE: Gastric ulcers (GU) are a disease of the gastrointestinal tract that can be caused by excessive alcohol consumption and heavy use of nonsteroidal anti-inflammatory drugs. GU manifests predominantly as pathological damage, such as extensive inflammatory erosion and superficial bleeding of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Zhiwei, Shi, Yannan, Wang, Hengcai, Chun, Changju, Chen, Longwang, Wang, Kang, Lu, Zhongqiu, Zhao, Yingzheng, Li, Xinze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709796/
https://www.ncbi.nlm.nih.gov/pubmed/34992363
http://dx.doi.org/10.2147/IJN.S344805
_version_ 1784623022346338304
author Huang, Zhiwei
Shi, Yannan
Wang, Hengcai
Chun, Changju
Chen, Longwang
Wang, Kang
Lu, Zhongqiu
Zhao, Yingzheng
Li, Xinze
author_facet Huang, Zhiwei
Shi, Yannan
Wang, Hengcai
Chun, Changju
Chen, Longwang
Wang, Kang
Lu, Zhongqiu
Zhao, Yingzheng
Li, Xinze
author_sort Huang, Zhiwei
collection PubMed
description PURPOSE: Gastric ulcers (GU) are a disease of the gastrointestinal tract that can be caused by excessive alcohol consumption and heavy use of nonsteroidal anti-inflammatory drugs. GU manifests predominantly as pathological damage, such as extensive inflammatory erosion and superficial bleeding of the gastric mucosa. Oxidative stress damage and the inflammatory response are now considered important predisposing factors for GU, suggesting that antioxidant and anti-inflammatory drugs could be treatments for GU. Nanoparticle drug carriers offer many advantages over conventional drugs, such as improved drug efficiency, increased drug stability, and increased half-life. METHODS: We designed chitosan-bilirubin conjugate (CS-BR) nanoparticles and assessed the anti-inflammatory and antioxidant abilities of CS-BR in gastric epithelial cells. Then, we evaluated the intragastric retention time and the anti-ulcer effects of CS-BR in vivo. RESULTS: The in vitro data showed that CS-BR nanoparticles protect gastric epithelial cells against oxidative/inflammatory injury. The in vivo study demonstrated that CS-BR nanoparticles accumulate permanently in the stomach and exert powerful antioxidant and anti-inflammatory effects against GU. CONCLUSION: This study applied bilirubin to the treatment of GU and confirmed that CS-BR nanoparticles are effective at alleviating acute GU in an experimental model. The findings provide innovative ideas for prophylaxis against or treatment of GU.
format Online
Article
Text
id pubmed-8709796
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-87097962022-01-05 Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers Huang, Zhiwei Shi, Yannan Wang, Hengcai Chun, Changju Chen, Longwang Wang, Kang Lu, Zhongqiu Zhao, Yingzheng Li, Xinze Int J Nanomedicine Original Research PURPOSE: Gastric ulcers (GU) are a disease of the gastrointestinal tract that can be caused by excessive alcohol consumption and heavy use of nonsteroidal anti-inflammatory drugs. GU manifests predominantly as pathological damage, such as extensive inflammatory erosion and superficial bleeding of the gastric mucosa. Oxidative stress damage and the inflammatory response are now considered important predisposing factors for GU, suggesting that antioxidant and anti-inflammatory drugs could be treatments for GU. Nanoparticle drug carriers offer many advantages over conventional drugs, such as improved drug efficiency, increased drug stability, and increased half-life. METHODS: We designed chitosan-bilirubin conjugate (CS-BR) nanoparticles and assessed the anti-inflammatory and antioxidant abilities of CS-BR in gastric epithelial cells. Then, we evaluated the intragastric retention time and the anti-ulcer effects of CS-BR in vivo. RESULTS: The in vitro data showed that CS-BR nanoparticles protect gastric epithelial cells against oxidative/inflammatory injury. The in vivo study demonstrated that CS-BR nanoparticles accumulate permanently in the stomach and exert powerful antioxidant and anti-inflammatory effects against GU. CONCLUSION: This study applied bilirubin to the treatment of GU and confirmed that CS-BR nanoparticles are effective at alleviating acute GU in an experimental model. The findings provide innovative ideas for prophylaxis against or treatment of GU. Dove 2021-12-20 /pmc/articles/PMC8709796/ /pubmed/34992363 http://dx.doi.org/10.2147/IJN.S344805 Text en © 2021 Huang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Huang, Zhiwei
Shi, Yannan
Wang, Hengcai
Chun, Changju
Chen, Longwang
Wang, Kang
Lu, Zhongqiu
Zhao, Yingzheng
Li, Xinze
Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers
title Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers
title_full Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers
title_fullStr Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers
title_full_unstemmed Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers
title_short Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers
title_sort protective effects of chitosan-bilirubin nanoparticles against ethanol-induced gastric ulcers
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709796/
https://www.ncbi.nlm.nih.gov/pubmed/34992363
http://dx.doi.org/10.2147/IJN.S344805
work_keys_str_mv AT huangzhiwei protectiveeffectsofchitosanbilirubinnanoparticlesagainstethanolinducedgastriculcers
AT shiyannan protectiveeffectsofchitosanbilirubinnanoparticlesagainstethanolinducedgastriculcers
AT wanghengcai protectiveeffectsofchitosanbilirubinnanoparticlesagainstethanolinducedgastriculcers
AT chunchangju protectiveeffectsofchitosanbilirubinnanoparticlesagainstethanolinducedgastriculcers
AT chenlongwang protectiveeffectsofchitosanbilirubinnanoparticlesagainstethanolinducedgastriculcers
AT wangkang protectiveeffectsofchitosanbilirubinnanoparticlesagainstethanolinducedgastriculcers
AT luzhongqiu protectiveeffectsofchitosanbilirubinnanoparticlesagainstethanolinducedgastriculcers
AT zhaoyingzheng protectiveeffectsofchitosanbilirubinnanoparticlesagainstethanolinducedgastriculcers
AT lixinze protectiveeffectsofchitosanbilirubinnanoparticlesagainstethanolinducedgastriculcers