Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon

Keratin 8 (K8) is the main intestinal epithelial intermediate filament protein with proposed roles for colonic epithelial cell integrity. Here, we used mice lacking K8 in intestinal epithelial cells (floxed K8 and Villin-Cre1000 and Villin-CreER(t2)) to investigate the cell-specific roles of intesti...

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Detalles Bibliográficos
Autores principales: Stenvall, Carl-Gustaf A., Tayyab, Mina, Grönroos, Tove J., Ilomäki, Maria A., Viiri, Keijo, Ridge, Karen M., Polari, Lauri, Toivola, Diana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709826/
https://www.ncbi.nlm.nih.gov/pubmed/34951664
http://dx.doi.org/10.1007/s00018-021-04081-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709826/
https://www.ncbi.nlm.nih.gov/pubmed/34951664
http://dx.doi.org/10.1007/s00018-021-04081-5

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