SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To stud...

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Detalles Bibliográficos
Autores principales: Jansen, Jitske, Reimer, Katharina C., Nagai, James S., Varghese, Finny S., Overheul, Gijs J., de Beer, Marit, Roverts, Rona, Daviran, Deniz, Fermin, Liline A.S., Willemsen, Brigith, Beukenboom, Marcel, Djudjaj, Sonja, von Stillfried, Saskia, van Eijk, Larissa E., Mastik, Mirjam, Bulthuis, Marian, Dunnen, Wilfred den, van Goor, Harry, Hillebrands, Jan-Luuk, Triana, Sergio H., Alexandrov, Theodore, Timm, Marie-Cherelle, van den Berge, Bartholomeus T., van den Broek, Martijn, Nlandu, Quincy, Heijnert, Joelle, Bindels, Eric M.J., Hoogenboezem, Remco M., Mooren, Fieke, Kuppe, Christoph, Miesen, Pascal, Grünberg, Katrien, Ijzermans, Ties, Steenbergen, Eric J., Czogalla, Jan, Schreuder, Michiel F., Sommerdijk, Nico, Akiva, Anat, Boor, Peter, Puelles, Victor G., Floege, Jürgen, Huber, Tobias B., van Rij, Ronald P., Costa, Ivan G., Schneider, Rebekka K., Smeets, Bart, Kramann, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Clinical and Translational Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709832/
https://www.ncbi.nlm.nih.gov/pubmed/35032430
http://dx.doi.org/10.1016/j.stem.2021.12.010

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