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The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age
Midlife lipid levels are important predictors of cardiovascular diseases, yet their association with mortality in older adults is less clear. We aimed to (1) identify lipid profiles based on cholesterol, triglycerides, and apolipoproteins using cluster analysis, and (2) investigate how lipid profile...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709841/ https://www.ncbi.nlm.nih.gov/pubmed/34952923 http://dx.doi.org/10.1038/s41598-021-03959-5 |
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author | Ding, Mozhu Wennberg, Alexandra Ek, Stina Santoni, Giola Gigante, Bruna Walldius, Göran Hammar, Niklas Modig, Karin |
author_facet | Ding, Mozhu Wennberg, Alexandra Ek, Stina Santoni, Giola Gigante, Bruna Walldius, Göran Hammar, Niklas Modig, Karin |
author_sort | Ding, Mozhu |
collection | PubMed |
description | Midlife lipid levels are important predictors of cardiovascular diseases, yet their association with mortality in older adults is less clear. We aimed to (1) identify lipid profiles based on cholesterol, triglycerides, and apolipoproteins using cluster analysis, and (2) investigate how lipid profiles and lipid levels at different ages are associated with later-life all-cause and cardiovascular mortality. We used data from 98,270 individuals in the Swedish AMORIS cohort who had blood measurements between 1985–1996 and were followed until 2012. Over the follow-up (mean 18.0 years), 30,730 (31.3%) individuals died. Three lipid profiles were identified. Compared with reference profile, a high lipid profile (low ApoA-I and high total cholesterol (TC), triglycerides, ApoB, and ApoB/ApoA-I ratio) at ages 39–59 or 60–79 was associated with higher all-cause mortality. A high lipid profile at ≥ 80 years, however, did not confer higher mortality. For the specific markers, high TC (≥ 7.25 mmol/L) was associated with higher all-cause mortality in ages 39–59 but lower mortality in ages 60–79 and ≥ 80. Low ApoA-I (< 1.28 g/L) and high ApoB/ApoA-I ratio (≥ 1.18), on the other hand, were associated with higher cardiovascular mortality regardless of age at lipid measurement, highlighting their potential relevance for survival in both young and older individuals. |
format | Online Article Text |
id | pubmed-8709841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-87098412021-12-28 The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age Ding, Mozhu Wennberg, Alexandra Ek, Stina Santoni, Giola Gigante, Bruna Walldius, Göran Hammar, Niklas Modig, Karin Sci Rep Article Midlife lipid levels are important predictors of cardiovascular diseases, yet their association with mortality in older adults is less clear. We aimed to (1) identify lipid profiles based on cholesterol, triglycerides, and apolipoproteins using cluster analysis, and (2) investigate how lipid profiles and lipid levels at different ages are associated with later-life all-cause and cardiovascular mortality. We used data from 98,270 individuals in the Swedish AMORIS cohort who had blood measurements between 1985–1996 and were followed until 2012. Over the follow-up (mean 18.0 years), 30,730 (31.3%) individuals died. Three lipid profiles were identified. Compared with reference profile, a high lipid profile (low ApoA-I and high total cholesterol (TC), triglycerides, ApoB, and ApoB/ApoA-I ratio) at ages 39–59 or 60–79 was associated with higher all-cause mortality. A high lipid profile at ≥ 80 years, however, did not confer higher mortality. For the specific markers, high TC (≥ 7.25 mmol/L) was associated with higher all-cause mortality in ages 39–59 but lower mortality in ages 60–79 and ≥ 80. Low ApoA-I (< 1.28 g/L) and high ApoB/ApoA-I ratio (≥ 1.18), on the other hand, were associated with higher cardiovascular mortality regardless of age at lipid measurement, highlighting their potential relevance for survival in both young and older individuals. Nature Publishing Group UK 2021-12-24 /pmc/articles/PMC8709841/ /pubmed/34952923 http://dx.doi.org/10.1038/s41598-021-03959-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ding, Mozhu Wennberg, Alexandra Ek, Stina Santoni, Giola Gigante, Bruna Walldius, Göran Hammar, Niklas Modig, Karin The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age |
title | The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age |
title_full | The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age |
title_fullStr | The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age |
title_full_unstemmed | The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age |
title_short | The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age |
title_sort | association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709841/ https://www.ncbi.nlm.nih.gov/pubmed/34952923 http://dx.doi.org/10.1038/s41598-021-03959-5 |
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