CTLA4-Ig treatment induces M1–M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients

BACKGROUND: In rheumatoid arthritis (RA), macrophages play an important role in modulating the immunoinflammatory response through their polarisation into “classically” (M1) or “alternatively activated” (M2) phenotypes. In RA, CTLA4-Ig (abatacept) reduces the inflammatory activity of macrophages by...

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Detalles Bibliográficos
Autores principales: Cutolo, Maurizio, Soldano, Stefano, Gotelli, Emanuele, Montagna, Paola, Campitiello, Rosanna, Paolino, Sabrina, Pizzorni, Carmen, Sulli, Alberto, Smith, Vanessa, Tardito, Samuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709961/
https://www.ncbi.nlm.nih.gov/pubmed/34952630
http://dx.doi.org/10.1186/s13075-021-02691-9

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