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The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells

BACKGROUND: Cervical cancers are closely associated with persistent high-risk human papillomaviruses (HR HPV) infection. The main mechanism involves the targeting of tumor suppressors, such as p53 and pRB, for degradation by HR HPV-encoded oncoproteins, thereby leading to tumorigenesis. Rap1GAP, a t...

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Detalles Bibliográficos
Autores principales:	Wang, Yinghui, Xie, Yihang, Sun, Boxuan, Guo, Yuwei, Song, Ling, Mohammednur, Dawit Eman, Zhao, Chunyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710002/ https://www.ncbi.nlm.nih.gov/pubmed/34952616 http://dx.doi.org/10.1186/s13027-021-00409-9

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