Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms

We evaluated a rapid antigen test against SARS-CoV-2 virus (Roche-SD Biosensor; RSDB-RAT) in children and adults with respiratory symptoms compared to those with nonrespiratory symptoms or asymptomatic. Also the performance of RSDB-RAT with respect to the duration of respiratory symptoms was assesse...

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Autores principales: Flinck, Heini, Kerimov, Dominik, Luukinen, Bruno, Seiskari, Tapio, Aittoniemi, Janne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710133/
https://www.ncbi.nlm.nih.gov/pubmed/35066397
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115628
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author Flinck, Heini
Kerimov, Dominik
Luukinen, Bruno
Seiskari, Tapio
Aittoniemi, Janne
author_facet Flinck, Heini
Kerimov, Dominik
Luukinen, Bruno
Seiskari, Tapio
Aittoniemi, Janne
author_sort Flinck, Heini
collection PubMed
description We evaluated a rapid antigen test against SARS-CoV-2 virus (Roche-SD Biosensor; RSDB-RAT) in children and adults with respiratory symptoms compared to those with nonrespiratory symptoms or asymptomatic. Also the performance of RSDB-RAT with respect to the duration of respiratory symptoms was assessed. A viral cross-reactivity panel was included. RSDB-RAT was reliable in detecting SARS-CoV-2 in children and adults if the respiratory symptoms had endured 1 to 7 days. If the respiratory symptoms had lasted less than 1 day, the sensitivity was significantly lower. No cross-reactivity with other respiratory viruses was observed.
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spelling pubmed-87101332021-12-28 Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms Flinck, Heini Kerimov, Dominik Luukinen, Bruno Seiskari, Tapio Aittoniemi, Janne Diagn Microbiol Infect Dis Article We evaluated a rapid antigen test against SARS-CoV-2 virus (Roche-SD Biosensor; RSDB-RAT) in children and adults with respiratory symptoms compared to those with nonrespiratory symptoms or asymptomatic. Also the performance of RSDB-RAT with respect to the duration of respiratory symptoms was assessed. A viral cross-reactivity panel was included. RSDB-RAT was reliable in detecting SARS-CoV-2 in children and adults if the respiratory symptoms had endured 1 to 7 days. If the respiratory symptoms had lasted less than 1 day, the sensitivity was significantly lower. No cross-reactivity with other respiratory viruses was observed. Elsevier Inc. 2022-04 2021-12-25 /pmc/articles/PMC8710133/ /pubmed/35066397 http://dx.doi.org/10.1016/j.diagmicrobio.2021.115628 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Flinck, Heini
Kerimov, Dominik
Luukinen, Bruno
Seiskari, Tapio
Aittoniemi, Janne
Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms
title Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms
title_full Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms
title_fullStr Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms
title_full_unstemmed Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms
title_short Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms
title_sort evaluation of the roche-sd biosensor rapid antigen test: antigen is not reliable in detecting sars-cov-2 at the early stage of infection with respiratory symptoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710133/
https://www.ncbi.nlm.nih.gov/pubmed/35066397
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115628
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