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Bradyarrhythmias in Cardio-Oncology

The relationship between bradyarrhythmias and cancer therapies has not been well described but is increasingly recognized. There have been extensive advances in oncological pharmacotherapy, with several new classes of drugs available including targeted agents, immune checkpoint inhibitors and CAR T...

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Autores principales: Fonseca, Marta, Cheng, Evaline, Do, Duc, Haldar, Shouvik, Kutty, Shelby, Yang, Eric H., Ghosh, Arjun K., Guha, Avirup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Private Ltd 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710146/
https://www.ncbi.nlm.nih.gov/pubmed/34966697
http://dx.doi.org/10.1055/s-0041-1731907
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author Fonseca, Marta
Cheng, Evaline
Do, Duc
Haldar, Shouvik
Kutty, Shelby
Yang, Eric H.
Ghosh, Arjun K.
Guha, Avirup
author_facet Fonseca, Marta
Cheng, Evaline
Do, Duc
Haldar, Shouvik
Kutty, Shelby
Yang, Eric H.
Ghosh, Arjun K.
Guha, Avirup
author_sort Fonseca, Marta
collection PubMed
description The relationship between bradyarrhythmias and cancer therapies has not been well described but is increasingly recognized. There have been extensive advances in oncological pharmacotherapy, with several new classes of drugs available including targeted agents, immune checkpoint inhibitors and CAR T cell therapy. This increasing repertoire of available drugs has revolutionized overall prognosis and survival of cancer patients but the true extent of their cardiovascular toxicity is only beginning to be understood. Previous studies and published reviews have traditionally focused on conventional chemotherapies and in arrhythmias in general, particularly tachyarrhythmias. The number of patients with both cancer and cardiovascular problems is increasing globally and oncologists and cardiologists need to be adept at managing arrythmia based scenarios. Greater collaboration between the two specialties including studies with prospective data collection in Cardio-Oncology are much needed to fill in knowledge gaps in this arena. This case-based review summarizes current available evidence of cancer treatment-related bradyarrhythmia incidence (including its different subtypes), possible mechanisms and outcomes. Furthermore, we propose a stepwise surveillance and management protocol for patients with suspected bradyarrhythmia related to cancer treatment.
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spelling pubmed-87101462021-12-28 Bradyarrhythmias in Cardio-Oncology Fonseca, Marta Cheng, Evaline Do, Duc Haldar, Shouvik Kutty, Shelby Yang, Eric H. Ghosh, Arjun K. Guha, Avirup South Asian J Cancer The relationship between bradyarrhythmias and cancer therapies has not been well described but is increasingly recognized. There have been extensive advances in oncological pharmacotherapy, with several new classes of drugs available including targeted agents, immune checkpoint inhibitors and CAR T cell therapy. This increasing repertoire of available drugs has revolutionized overall prognosis and survival of cancer patients but the true extent of their cardiovascular toxicity is only beginning to be understood. Previous studies and published reviews have traditionally focused on conventional chemotherapies and in arrhythmias in general, particularly tachyarrhythmias. The number of patients with both cancer and cardiovascular problems is increasing globally and oncologists and cardiologists need to be adept at managing arrythmia based scenarios. Greater collaboration between the two specialties including studies with prospective data collection in Cardio-Oncology are much needed to fill in knowledge gaps in this arena. This case-based review summarizes current available evidence of cancer treatment-related bradyarrhythmia incidence (including its different subtypes), possible mechanisms and outcomes. Furthermore, we propose a stepwise surveillance and management protocol for patients with suspected bradyarrhythmia related to cancer treatment. Thieme Medical and Scientific Publishers Private Ltd 2021-10-15 /pmc/articles/PMC8710146/ /pubmed/34966697 http://dx.doi.org/10.1055/s-0041-1731907 Text en MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Fonseca, Marta
Cheng, Evaline
Do, Duc
Haldar, Shouvik
Kutty, Shelby
Yang, Eric H.
Ghosh, Arjun K.
Guha, Avirup
Bradyarrhythmias in Cardio-Oncology
title Bradyarrhythmias in Cardio-Oncology
title_full Bradyarrhythmias in Cardio-Oncology
title_fullStr Bradyarrhythmias in Cardio-Oncology
title_full_unstemmed Bradyarrhythmias in Cardio-Oncology
title_short Bradyarrhythmias in Cardio-Oncology
title_sort bradyarrhythmias in cardio-oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710146/
https://www.ncbi.nlm.nih.gov/pubmed/34966697
http://dx.doi.org/10.1055/s-0041-1731907
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