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Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice
BACKGROUND: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice. METHODS: Five experimental groups were conside...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Tehran University of Medical Sciences
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710210/ https://www.ncbi.nlm.nih.gov/pubmed/35082885 http://dx.doi.org/10.18502/ijpa.v16i4.7869 |
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author | Neitzke-Abreu, Herintha Coeto Caetano, Rhuan Carlos Souza Reinhold-Castro, Kárin Rosi Lima-Junior, Manoel Sebastião da Costa dos Santos, Wagner José Tenório de Alcantara Nogueira de Melo, Gessilda Cuman, Roberto Kenji Nakamura Aristides, Sandra Mara Alessi Silveira, Thais Gomes Verzignassi Lonardoni, Maria Valdrinez Campana |
author_facet | Neitzke-Abreu, Herintha Coeto Caetano, Rhuan Carlos Souza Reinhold-Castro, Kárin Rosi Lima-Junior, Manoel Sebastião da Costa dos Santos, Wagner José Tenório de Alcantara Nogueira de Melo, Gessilda Cuman, Roberto Kenji Nakamura Aristides, Sandra Mara Alessi Silveira, Thais Gomes Verzignassi Lonardoni, Maria Valdrinez Campana |
author_sort | Neitzke-Abreu, Herintha Coeto |
collection | PubMed |
description | BACKGROUND: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice. METHODS: Five experimental groups were considered: group 1 (L. braziliensis); group 2 (L. amazonensis); group 3 (L. major); group 4 (control group with PBS); group 5 (negative control group), analyzed 3, 6, 12, and 24 h after parasite inoculation. RESULTS: Infections by the different Leishmania species caused an increase in the number of rolling leukocytes: L. braziliensis a peak at 6 h; L. amazonensis and L. major a peak at 3 h. The Leishmania infections induced leukocyte adhesion: L. major and L. amazonensis showed an increase after 3 and 6 h, respectively. CONCLUSION: The kinetics of cellular recruitment in Leishmania infections, leading to infection susceptibility or resistance, indicates that distinct mechanisms regulate the initial response to Leishmania infection and determine its course. |
format | Online Article Text |
id | pubmed-8710210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-87102102022-01-25 Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice Neitzke-Abreu, Herintha Coeto Caetano, Rhuan Carlos Souza Reinhold-Castro, Kárin Rosi Lima-Junior, Manoel Sebastião da Costa dos Santos, Wagner José Tenório de Alcantara Nogueira de Melo, Gessilda Cuman, Roberto Kenji Nakamura Aristides, Sandra Mara Alessi Silveira, Thais Gomes Verzignassi Lonardoni, Maria Valdrinez Campana Iran J Parasitol Original Article BACKGROUND: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice. METHODS: Five experimental groups were considered: group 1 (L. braziliensis); group 2 (L. amazonensis); group 3 (L. major); group 4 (control group with PBS); group 5 (negative control group), analyzed 3, 6, 12, and 24 h after parasite inoculation. RESULTS: Infections by the different Leishmania species caused an increase in the number of rolling leukocytes: L. braziliensis a peak at 6 h; L. amazonensis and L. major a peak at 3 h. The Leishmania infections induced leukocyte adhesion: L. major and L. amazonensis showed an increase after 3 and 6 h, respectively. CONCLUSION: The kinetics of cellular recruitment in Leishmania infections, leading to infection susceptibility or resistance, indicates that distinct mechanisms regulate the initial response to Leishmania infection and determine its course. Tehran University of Medical Sciences 2021 /pmc/articles/PMC8710210/ /pubmed/35082885 http://dx.doi.org/10.18502/ijpa.v16i4.7869 Text en Copyright © 2021 Neitzke-Abreu et al. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Original Article Neitzke-Abreu, Herintha Coeto Caetano, Rhuan Carlos Souza Reinhold-Castro, Kárin Rosi Lima-Junior, Manoel Sebastião da Costa dos Santos, Wagner José Tenório de Alcantara Nogueira de Melo, Gessilda Cuman, Roberto Kenji Nakamura Aristides, Sandra Mara Alessi Silveira, Thais Gomes Verzignassi Lonardoni, Maria Valdrinez Campana Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice |
title | Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice |
title_full | Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice |
title_fullStr | Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice |
title_full_unstemmed | Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice |
title_short | Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice |
title_sort | leukocyte behavior in mesenteric microcirculation upon experimental by leishmania spp. in balb/c mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710210/ https://www.ncbi.nlm.nih.gov/pubmed/35082885 http://dx.doi.org/10.18502/ijpa.v16i4.7869 |
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