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Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population
BACKGROUND: Asthma is a major source of global social and economic burden; thus, its early detection is important. Measurement of fractional exhaled nitric oxide (FENO) has been used recently considered a good indicator of asthma and also a sensitive and non-invasive method for monitoring airway inf...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Research Institute of Tuberculosis and Lung Disease
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710218/ https://www.ncbi.nlm.nih.gov/pubmed/34976086 |
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author | Borhani Fard, Mohammad Samet, Mohammad Salmani Nodoushan, Mojahede Mehrparvar, Amir Houshang Bahrami-Ahmadi, Amir |
author_facet | Borhani Fard, Mohammad Samet, Mohammad Salmani Nodoushan, Mojahede Mehrparvar, Amir Houshang Bahrami-Ahmadi, Amir |
author_sort | Borhani Fard, Mohammad |
collection | PubMed |
description | BACKGROUND: Asthma is a major source of global social and economic burden; thus, its early detection is important. Measurement of fractional exhaled nitric oxide (FENO) has been used recently considered a good indicator of asthma and also a sensitive and non-invasive method for monitoring airway inflammation. This study was conducted to determine the cut-off point of FENO for the diagnosis of asthma in the studied population. MATERIALS AND METHODS: The subjects of this cross-sectional diagnostic study were assessed by the FENO test, spirometry, and methacholine challenge test. The best cut-off point of the FENO for the diagnosis of asthma was determined. The data were analyzed by SPSS 20 using student t-test, and Chi-square test and the ROC curves were also drawn. RESULTS: The mean FENO in asthmatic and non-asthmatic subjects was 43.5±33.41 and 17.5±21.48 ppb, respectively (P <0.001). The best cut-off point of the FENO based on the overall sensitivity and specificity was 39.5 ppb. CONCLUSION: According to the results of this study, symptomatic patients with FENO higher than 39.5 ppb could be considered as asthmatic. |
format | Online Article Text |
id | pubmed-8710218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | National Research Institute of Tuberculosis and Lung Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-87102182021-12-30 Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population Borhani Fard, Mohammad Samet, Mohammad Salmani Nodoushan, Mojahede Mehrparvar, Amir Houshang Bahrami-Ahmadi, Amir Tanaffos Original Article BACKGROUND: Asthma is a major source of global social and economic burden; thus, its early detection is important. Measurement of fractional exhaled nitric oxide (FENO) has been used recently considered a good indicator of asthma and also a sensitive and non-invasive method for monitoring airway inflammation. This study was conducted to determine the cut-off point of FENO for the diagnosis of asthma in the studied population. MATERIALS AND METHODS: The subjects of this cross-sectional diagnostic study were assessed by the FENO test, spirometry, and methacholine challenge test. The best cut-off point of the FENO for the diagnosis of asthma was determined. The data were analyzed by SPSS 20 using student t-test, and Chi-square test and the ROC curves were also drawn. RESULTS: The mean FENO in asthmatic and non-asthmatic subjects was 43.5±33.41 and 17.5±21.48 ppb, respectively (P <0.001). The best cut-off point of the FENO based on the overall sensitivity and specificity was 39.5 ppb. CONCLUSION: According to the results of this study, symptomatic patients with FENO higher than 39.5 ppb could be considered as asthmatic. National Research Institute of Tuberculosis and Lung Disease 2021-02 /pmc/articles/PMC8710218/ /pubmed/34976086 Text en Copyright© 2021 National Research Institute of Tuberculosis and Lung Disease https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Original Article Borhani Fard, Mohammad Samet, Mohammad Salmani Nodoushan, Mojahede Mehrparvar, Amir Houshang Bahrami-Ahmadi, Amir Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population |
title | Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population |
title_full | Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population |
title_fullStr | Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population |
title_full_unstemmed | Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population |
title_short | Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population |
title_sort | determination of a cut-off point for exhaled nitric oxide in the diagnosis of asthma in an iranian population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710218/ https://www.ncbi.nlm.nih.gov/pubmed/34976086 |
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