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Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population

BACKGROUND: Asthma is a major source of global social and economic burden; thus, its early detection is important. Measurement of fractional exhaled nitric oxide (FENO) has been used recently considered a good indicator of asthma and also a sensitive and non-invasive method for monitoring airway inf...

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Autores principales: Borhani Fard, Mohammad, Samet, Mohammad, Salmani Nodoushan, Mojahede, Mehrparvar, Amir Houshang, Bahrami-Ahmadi, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710218/
https://www.ncbi.nlm.nih.gov/pubmed/34976086
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author Borhani Fard, Mohammad
Samet, Mohammad
Salmani Nodoushan, Mojahede
Mehrparvar, Amir Houshang
Bahrami-Ahmadi, Amir
author_facet Borhani Fard, Mohammad
Samet, Mohammad
Salmani Nodoushan, Mojahede
Mehrparvar, Amir Houshang
Bahrami-Ahmadi, Amir
author_sort Borhani Fard, Mohammad
collection PubMed
description BACKGROUND: Asthma is a major source of global social and economic burden; thus, its early detection is important. Measurement of fractional exhaled nitric oxide (FENO) has been used recently considered a good indicator of asthma and also a sensitive and non-invasive method for monitoring airway inflammation. This study was conducted to determine the cut-off point of FENO for the diagnosis of asthma in the studied population. MATERIALS AND METHODS: The subjects of this cross-sectional diagnostic study were assessed by the FENO test, spirometry, and methacholine challenge test. The best cut-off point of the FENO for the diagnosis of asthma was determined. The data were analyzed by SPSS 20 using student t-test, and Chi-square test and the ROC curves were also drawn. RESULTS: The mean FENO in asthmatic and non-asthmatic subjects was 43.5±33.41 and 17.5±21.48 ppb, respectively (P <0.001). The best cut-off point of the FENO based on the overall sensitivity and specificity was 39.5 ppb. CONCLUSION: According to the results of this study, symptomatic patients with FENO higher than 39.5 ppb could be considered as asthmatic.
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spelling pubmed-87102182021-12-30 Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population Borhani Fard, Mohammad Samet, Mohammad Salmani Nodoushan, Mojahede Mehrparvar, Amir Houshang Bahrami-Ahmadi, Amir Tanaffos Original Article BACKGROUND: Asthma is a major source of global social and economic burden; thus, its early detection is important. Measurement of fractional exhaled nitric oxide (FENO) has been used recently considered a good indicator of asthma and also a sensitive and non-invasive method for monitoring airway inflammation. This study was conducted to determine the cut-off point of FENO for the diagnosis of asthma in the studied population. MATERIALS AND METHODS: The subjects of this cross-sectional diagnostic study were assessed by the FENO test, spirometry, and methacholine challenge test. The best cut-off point of the FENO for the diagnosis of asthma was determined. The data were analyzed by SPSS 20 using student t-test, and Chi-square test and the ROC curves were also drawn. RESULTS: The mean FENO in asthmatic and non-asthmatic subjects was 43.5±33.41 and 17.5±21.48 ppb, respectively (P <0.001). The best cut-off point of the FENO based on the overall sensitivity and specificity was 39.5 ppb. CONCLUSION: According to the results of this study, symptomatic patients with FENO higher than 39.5 ppb could be considered as asthmatic. National Research Institute of Tuberculosis and Lung Disease 2021-02 /pmc/articles/PMC8710218/ /pubmed/34976086 Text en Copyright© 2021 National Research Institute of Tuberculosis and Lung Disease https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Original Article
Borhani Fard, Mohammad
Samet, Mohammad
Salmani Nodoushan, Mojahede
Mehrparvar, Amir Houshang
Bahrami-Ahmadi, Amir
Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population
title Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population
title_full Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population
title_fullStr Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population
title_full_unstemmed Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population
title_short Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population
title_sort determination of a cut-off point for exhaled nitric oxide in the diagnosis of asthma in an iranian population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710218/
https://www.ncbi.nlm.nih.gov/pubmed/34976086
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