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An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients

BACKGROUND: In cystic fibrosis patients, the mucus is an excellent place for opportunistic bacteria and pathogens to cover. Chronic infections of upper and lower airways play a critical role in the mortality of cystic fibrosis. This study aimed to introduce the microbiota profiles in patients with c...

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Autores principales: Meskini, Maryam, Siadat, Seyed Davar, Seifi, Sharareh, Movafagh, Abolfazl, Sheikhpour, Mojgan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710221/
https://www.ncbi.nlm.nih.gov/pubmed/34976079
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author Meskini, Maryam
Siadat, Seyed Davar
Seifi, Sharareh
Movafagh, Abolfazl
Sheikhpour, Mojgan
author_facet Meskini, Maryam
Siadat, Seyed Davar
Seifi, Sharareh
Movafagh, Abolfazl
Sheikhpour, Mojgan
author_sort Meskini, Maryam
collection PubMed
description BACKGROUND: In cystic fibrosis patients, the mucus is an excellent place for opportunistic bacteria and pathogens to cover. Chronic infections of upper and lower airways play a critical role in the mortality of cystic fibrosis. This study aimed to introduce the microbiota profiles in patients with cystic fibrosis. MATERIALS AND METHODS: In this study, a comprehensive literature search was done for studies on upper and lower airway microbiota in cystic fibrosis patients. International and national databases were searched for the following MeSH words: microbiota, microbiome, upper airway, lower airway, cystic fibrosis, cystic fibrosis, upper airway microbiome, lower airway microbiome, microbiome pattern in cystic fibrosis, microbiome pattern in cystic fibrosis, upper airway microbiota, lower airway microbiota, and microbiota pattern. RESULTS: Streptococcus spp. are in significantly higher relative abundance in infants and children with cystic fibrosis; however, Pseudomonas spp. are in higher relative abundance in adults with cystic fibrosis. Molecular diagnostic techniques can be remarkably accurate in detecting microbial strains. CONCLUSION: For the detection and isolation of most bacterial species, independent-culture methods in addition to the standard culture method are recommended, and sampling should include both upper and lower airways.
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spelling pubmed-87102212021-12-30 An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients Meskini, Maryam Siadat, Seyed Davar Seifi, Sharareh Movafagh, Abolfazl Sheikhpour, Mojgan Tanaffos Review Article BACKGROUND: In cystic fibrosis patients, the mucus is an excellent place for opportunistic bacteria and pathogens to cover. Chronic infections of upper and lower airways play a critical role in the mortality of cystic fibrosis. This study aimed to introduce the microbiota profiles in patients with cystic fibrosis. MATERIALS AND METHODS: In this study, a comprehensive literature search was done for studies on upper and lower airway microbiota in cystic fibrosis patients. International and national databases were searched for the following MeSH words: microbiota, microbiome, upper airway, lower airway, cystic fibrosis, cystic fibrosis, upper airway microbiome, lower airway microbiome, microbiome pattern in cystic fibrosis, microbiome pattern in cystic fibrosis, upper airway microbiota, lower airway microbiota, and microbiota pattern. RESULTS: Streptococcus spp. are in significantly higher relative abundance in infants and children with cystic fibrosis; however, Pseudomonas spp. are in higher relative abundance in adults with cystic fibrosis. Molecular diagnostic techniques can be remarkably accurate in detecting microbial strains. CONCLUSION: For the detection and isolation of most bacterial species, independent-culture methods in addition to the standard culture method are recommended, and sampling should include both upper and lower airways. National Research Institute of Tuberculosis and Lung Disease 2021-02 /pmc/articles/PMC8710221/ /pubmed/34976079 Text en Copyright© 2021 National Research Institute of Tuberculosis and Lung Disease https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Review Article
Meskini, Maryam
Siadat, Seyed Davar
Seifi, Sharareh
Movafagh, Abolfazl
Sheikhpour, Mojgan
An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients
title An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients
title_full An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients
title_fullStr An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients
title_full_unstemmed An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients
title_short An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients
title_sort overview on the upper and lower airway microbiome in cystic fibrosis patients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710221/
https://www.ncbi.nlm.nih.gov/pubmed/34976079
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