Cargando…
An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients
BACKGROUND: In cystic fibrosis patients, the mucus is an excellent place for opportunistic bacteria and pathogens to cover. Chronic infections of upper and lower airways play a critical role in the mortality of cystic fibrosis. This study aimed to introduce the microbiota profiles in patients with c...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Research Institute of Tuberculosis and Lung Disease
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710221/ https://www.ncbi.nlm.nih.gov/pubmed/34976079 |
_version_ | 1784623113663676416 |
---|---|
author | Meskini, Maryam Siadat, Seyed Davar Seifi, Sharareh Movafagh, Abolfazl Sheikhpour, Mojgan |
author_facet | Meskini, Maryam Siadat, Seyed Davar Seifi, Sharareh Movafagh, Abolfazl Sheikhpour, Mojgan |
author_sort | Meskini, Maryam |
collection | PubMed |
description | BACKGROUND: In cystic fibrosis patients, the mucus is an excellent place for opportunistic bacteria and pathogens to cover. Chronic infections of upper and lower airways play a critical role in the mortality of cystic fibrosis. This study aimed to introduce the microbiota profiles in patients with cystic fibrosis. MATERIALS AND METHODS: In this study, a comprehensive literature search was done for studies on upper and lower airway microbiota in cystic fibrosis patients. International and national databases were searched for the following MeSH words: microbiota, microbiome, upper airway, lower airway, cystic fibrosis, cystic fibrosis, upper airway microbiome, lower airway microbiome, microbiome pattern in cystic fibrosis, microbiome pattern in cystic fibrosis, upper airway microbiota, lower airway microbiota, and microbiota pattern. RESULTS: Streptococcus spp. are in significantly higher relative abundance in infants and children with cystic fibrosis; however, Pseudomonas spp. are in higher relative abundance in adults with cystic fibrosis. Molecular diagnostic techniques can be remarkably accurate in detecting microbial strains. CONCLUSION: For the detection and isolation of most bacterial species, independent-culture methods in addition to the standard culture method are recommended, and sampling should include both upper and lower airways. |
format | Online Article Text |
id | pubmed-8710221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | National Research Institute of Tuberculosis and Lung Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-87102212021-12-30 An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients Meskini, Maryam Siadat, Seyed Davar Seifi, Sharareh Movafagh, Abolfazl Sheikhpour, Mojgan Tanaffos Review Article BACKGROUND: In cystic fibrosis patients, the mucus is an excellent place for opportunistic bacteria and pathogens to cover. Chronic infections of upper and lower airways play a critical role in the mortality of cystic fibrosis. This study aimed to introduce the microbiota profiles in patients with cystic fibrosis. MATERIALS AND METHODS: In this study, a comprehensive literature search was done for studies on upper and lower airway microbiota in cystic fibrosis patients. International and national databases were searched for the following MeSH words: microbiota, microbiome, upper airway, lower airway, cystic fibrosis, cystic fibrosis, upper airway microbiome, lower airway microbiome, microbiome pattern in cystic fibrosis, microbiome pattern in cystic fibrosis, upper airway microbiota, lower airway microbiota, and microbiota pattern. RESULTS: Streptococcus spp. are in significantly higher relative abundance in infants and children with cystic fibrosis; however, Pseudomonas spp. are in higher relative abundance in adults with cystic fibrosis. Molecular diagnostic techniques can be remarkably accurate in detecting microbial strains. CONCLUSION: For the detection and isolation of most bacterial species, independent-culture methods in addition to the standard culture method are recommended, and sampling should include both upper and lower airways. National Research Institute of Tuberculosis and Lung Disease 2021-02 /pmc/articles/PMC8710221/ /pubmed/34976079 Text en Copyright© 2021 National Research Institute of Tuberculosis and Lung Disease https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Review Article Meskini, Maryam Siadat, Seyed Davar Seifi, Sharareh Movafagh, Abolfazl Sheikhpour, Mojgan An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients |
title | An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients |
title_full | An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients |
title_fullStr | An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients |
title_full_unstemmed | An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients |
title_short | An Overview on the Upper and Lower Airway Microbiome in Cystic Fibrosis Patients |
title_sort | overview on the upper and lower airway microbiome in cystic fibrosis patients |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710221/ https://www.ncbi.nlm.nih.gov/pubmed/34976079 |
work_keys_str_mv | AT meskinimaryam anoverviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients AT siadatseyeddavar anoverviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients AT seifisharareh anoverviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients AT movafaghabolfazl anoverviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients AT sheikhpourmojgan anoverviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients AT meskinimaryam overviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients AT siadatseyeddavar overviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients AT seifisharareh overviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients AT movafaghabolfazl overviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients AT sheikhpourmojgan overviewontheupperandlowerairwaymicrobiomeincysticfibrosispatients |