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SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system
To gain insights on the heterogeneity of immune responses to vaccination against SARS-CoV-2 and to identify factors that could make individuals vulnerable to infection due to lack of response to vaccination, our hospital started offering free voluntary post-antibody testing against the spike protein...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710236/ https://www.ncbi.nlm.nih.gov/pubmed/34977312 http://dx.doi.org/10.1016/j.plabm.2021.e00261 |
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author | Devaraj, Sridevi Poventud-Fuentes, Izmarie Girotto, Matthew Monroe, Jermaine Boom, Julie Delclos, George Versalovic, James |
author_facet | Devaraj, Sridevi Poventud-Fuentes, Izmarie Girotto, Matthew Monroe, Jermaine Boom, Julie Delclos, George Versalovic, James |
author_sort | Devaraj, Sridevi |
collection | PubMed |
description | To gain insights on the heterogeneity of immune responses to vaccination against SARS-CoV-2 and to identify factors that could make individuals vulnerable to infection due to lack of response to vaccination, our hospital started offering free voluntary post-antibody testing against the spike protein IgG for all fully vaccinated employees. Post-vaccination response against SARS-CoV-2 was assessed using the FDA-EUA approved VITROS anti-SARS-CoV-2 IgG immunometric assay specific to the spike protein. Out of a total of 3266 antibody tests performed in fully vaccinated Texas Children’s, 99.4% had a positive antibody response to the spike protein. From the 21 employees (0.6%) that had a negative response, 66.7% reported taking immunosuppressive drugs and/or biologics. Our data shows that most of the employees tested at our institution mounted an immune response to the immunogen in the vaccine. Post-vaccination antibody testing against SARS-CoV-2 can provide useful information to guide decisions about future vaccine doses. |
format | Online Article Text |
id | pubmed-8710236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-87102362021-12-28 SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system Devaraj, Sridevi Poventud-Fuentes, Izmarie Girotto, Matthew Monroe, Jermaine Boom, Julie Delclos, George Versalovic, James Pract Lab Med Article To gain insights on the heterogeneity of immune responses to vaccination against SARS-CoV-2 and to identify factors that could make individuals vulnerable to infection due to lack of response to vaccination, our hospital started offering free voluntary post-antibody testing against the spike protein IgG for all fully vaccinated employees. Post-vaccination response against SARS-CoV-2 was assessed using the FDA-EUA approved VITROS anti-SARS-CoV-2 IgG immunometric assay specific to the spike protein. Out of a total of 3266 antibody tests performed in fully vaccinated Texas Children’s, 99.4% had a positive antibody response to the spike protein. From the 21 employees (0.6%) that had a negative response, 66.7% reported taking immunosuppressive drugs and/or biologics. Our data shows that most of the employees tested at our institution mounted an immune response to the immunogen in the vaccine. Post-vaccination antibody testing against SARS-CoV-2 can provide useful information to guide decisions about future vaccine doses. Elsevier 2021-12-26 /pmc/articles/PMC8710236/ /pubmed/34977312 http://dx.doi.org/10.1016/j.plabm.2021.e00261 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Devaraj, Sridevi Poventud-Fuentes, Izmarie Girotto, Matthew Monroe, Jermaine Boom, Julie Delclos, George Versalovic, James SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system |
title | SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system |
title_full | SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system |
title_fullStr | SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system |
title_full_unstemmed | SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system |
title_short | SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system |
title_sort | sarscov-2 serostatus amongst vaccinated employees at a pediatric hospital system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710236/ https://www.ncbi.nlm.nih.gov/pubmed/34977312 http://dx.doi.org/10.1016/j.plabm.2021.e00261 |
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