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The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006

BACKGROUND: The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, several others reported the lack of any existing association. This study aimed to in...

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Autores principales: Li, Song, Zhao, Chu-Jin, Hua, Hong-Li, Deng, Yu-Qin, Tao, Ze-Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710243/
https://www.ncbi.nlm.nih.gov/pubmed/34953489
http://dx.doi.org/10.1186/s13223-021-00642-2
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author Li, Song
Zhao, Chu-Jin
Hua, Hong-Li
Deng, Yu-Qin
Tao, Ze-Zhang
author_facet Li, Song
Zhao, Chu-Jin
Hua, Hong-Li
Deng, Yu-Qin
Tao, Ze-Zhang
author_sort Li, Song
collection PubMed
description BACKGROUND: The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, several others reported the lack of any existing association. This study aimed to investigate the relationship between allergy and sinusitis. METHODS: We conducted a cross-sectional study using a representative sample of the US population from the National Health and Nutrition Examination Survey 2005‒2006 (n  = 7244). A self-reported allergy questionnaire and total and allergen-specific IgE levels were used for analysis. Participants were divided into positive and negative allergy symptoms groups (PAS, NAS, respectively) to eliminate the influence of allergy symptoms on the apparent incidence of sinusitis. Pearson’s chi-square test and the linear regression analysis using Durbin Watson test were used for statistical analysis. RESULTS: Sinusitis incidence in the PAS group (22.4%; 521/2327) was significantly higher than that in the NAS group (7.1%; 348/4917) [odds ratios (OR)  = 3.788, 95% confidence interval (CI) 3.272‒4.384, P  < 0.001]. sinusitis incidence in non-sensitized and sensitized groups was not statistically different. After controlling for allergy symptoms, there was a negative correlation between sensitization status and the occurrence of sinusitis in the PAS group (OR  = 1.407, 95% CI 1.156‒1.711, P  < 0.01). Increase in serum total IgE levels correlated with decrease in incidence of sinusitis in both PAS and NAS groups. sinusitis incidence was significantly reduced in the PAS group in participants sensitized to allergens such as cockroaches, ragweed, ryegrass, Bermuda grass, oak, birch, and thistle. CONCLUSION: Allergy is related to sinusitis incidence. It is likely that sensitization status could reduce the incidence of sinusitis, albeit in an antigen-specific manner.
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spelling pubmed-87102432022-01-05 The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006 Li, Song Zhao, Chu-Jin Hua, Hong-Li Deng, Yu-Qin Tao, Ze-Zhang Allergy Asthma Clin Immunol Research BACKGROUND: The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, several others reported the lack of any existing association. This study aimed to investigate the relationship between allergy and sinusitis. METHODS: We conducted a cross-sectional study using a representative sample of the US population from the National Health and Nutrition Examination Survey 2005‒2006 (n  = 7244). A self-reported allergy questionnaire and total and allergen-specific IgE levels were used for analysis. Participants were divided into positive and negative allergy symptoms groups (PAS, NAS, respectively) to eliminate the influence of allergy symptoms on the apparent incidence of sinusitis. Pearson’s chi-square test and the linear regression analysis using Durbin Watson test were used for statistical analysis. RESULTS: Sinusitis incidence in the PAS group (22.4%; 521/2327) was significantly higher than that in the NAS group (7.1%; 348/4917) [odds ratios (OR)  = 3.788, 95% confidence interval (CI) 3.272‒4.384, P  < 0.001]. sinusitis incidence in non-sensitized and sensitized groups was not statistically different. After controlling for allergy symptoms, there was a negative correlation between sensitization status and the occurrence of sinusitis in the PAS group (OR  = 1.407, 95% CI 1.156‒1.711, P  < 0.01). Increase in serum total IgE levels correlated with decrease in incidence of sinusitis in both PAS and NAS groups. sinusitis incidence was significantly reduced in the PAS group in participants sensitized to allergens such as cockroaches, ragweed, ryegrass, Bermuda grass, oak, birch, and thistle. CONCLUSION: Allergy is related to sinusitis incidence. It is likely that sensitization status could reduce the incidence of sinusitis, albeit in an antigen-specific manner. BioMed Central 2021-12-25 /pmc/articles/PMC8710243/ /pubmed/34953489 http://dx.doi.org/10.1186/s13223-021-00642-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Song
Zhao, Chu-Jin
Hua, Hong-Li
Deng, Yu-Qin
Tao, Ze-Zhang
The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006
title The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006
title_full The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006
title_fullStr The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006
title_full_unstemmed The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006
title_short The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006
title_sort association between allergy and sinusitis: a cross-sectional study based on nhanes 2005–2006
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710243/
https://www.ncbi.nlm.nih.gov/pubmed/34953489
http://dx.doi.org/10.1186/s13223-021-00642-2
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