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Microbe-based management for colorectal cancer

Colorectal cancer (CRC) is one of the most prevalent, most lethal cancers in the world. Increasing evidence suggests that the intestinal microbiota is closely related to the pathogenesis and prognosis of CRC. The normal microbiota plays an essential role in maintaining gut barrier function and the i...

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Autores principales: Gao, Zi-Yun, Cui, Zhe, Yan, Yu-Qing, Ning, Li-Jun, Wang, Zhen-Hua, Hong, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710322/
https://www.ncbi.nlm.nih.gov/pubmed/34855639
http://dx.doi.org/10.1097/CM9.0000000000001887
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author Gao, Zi-Yun
Cui, Zhe
Yan, Yu-Qing
Ning, Li-Jun
Wang, Zhen-Hua
Hong, Jie
author_facet Gao, Zi-Yun
Cui, Zhe
Yan, Yu-Qing
Ning, Li-Jun
Wang, Zhen-Hua
Hong, Jie
author_sort Gao, Zi-Yun
collection PubMed
description Colorectal cancer (CRC) is one of the most prevalent, most lethal cancers in the world. Increasing evidence suggests that the intestinal microbiota is closely related to the pathogenesis and prognosis of CRC. The normal microbiota plays an essential role in maintaining gut barrier function and the immune microenvironment. Recent studies have identified carcinogenic bacteria such as enterotoxigenic Bacteroides fragilis (ETBF) and Streptococcus gallolyticus (S. gallolyticus), as well as protective bacterial such as Akkermansia muciniphila (A. muciniphila), as potential targets of CRC treatment. Gut microbiota modulation aims to restore gut dysbiosis, regulate the intestinal immune system and prevent from pathogen invasion, all of which are beneficial for CRC prevention and prognosis. The utility of probiotics, prebiotics, postbiotics, fecal microbiota transplantation and dietary inventions to treat CRC makes them novel microbe-based management tools. In this review, we describe the mechanisms involved in bacteria-derived colorectal carcinogenesis and summarized novel bacteria-related therapies for CRC. In summary, we hope to facilitate clinical applications of intestinal bacteria for preventing and treating CRC.
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spelling pubmed-87103222021-12-28 Microbe-based management for colorectal cancer Gao, Zi-Yun Cui, Zhe Yan, Yu-Qing Ning, Li-Jun Wang, Zhen-Hua Hong, Jie Chin Med J (Engl) Review Article Colorectal cancer (CRC) is one of the most prevalent, most lethal cancers in the world. Increasing evidence suggests that the intestinal microbiota is closely related to the pathogenesis and prognosis of CRC. The normal microbiota plays an essential role in maintaining gut barrier function and the immune microenvironment. Recent studies have identified carcinogenic bacteria such as enterotoxigenic Bacteroides fragilis (ETBF) and Streptococcus gallolyticus (S. gallolyticus), as well as protective bacterial such as Akkermansia muciniphila (A. muciniphila), as potential targets of CRC treatment. Gut microbiota modulation aims to restore gut dysbiosis, regulate the intestinal immune system and prevent from pathogen invasion, all of which are beneficial for CRC prevention and prognosis. The utility of probiotics, prebiotics, postbiotics, fecal microbiota transplantation and dietary inventions to treat CRC makes them novel microbe-based management tools. In this review, we describe the mechanisms involved in bacteria-derived colorectal carcinogenesis and summarized novel bacteria-related therapies for CRC. In summary, we hope to facilitate clinical applications of intestinal bacteria for preventing and treating CRC. Lippincott Williams & Wilkins 2021-12-20 2021-12-01 /pmc/articles/PMC8710322/ /pubmed/34855639 http://dx.doi.org/10.1097/CM9.0000000000001887 Text en Copyright © 2021 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review Article
Gao, Zi-Yun
Cui, Zhe
Yan, Yu-Qing
Ning, Li-Jun
Wang, Zhen-Hua
Hong, Jie
Microbe-based management for colorectal cancer
title Microbe-based management for colorectal cancer
title_full Microbe-based management for colorectal cancer
title_fullStr Microbe-based management for colorectal cancer
title_full_unstemmed Microbe-based management for colorectal cancer
title_short Microbe-based management for colorectal cancer
title_sort microbe-based management for colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710322/
https://www.ncbi.nlm.nih.gov/pubmed/34855639
http://dx.doi.org/10.1097/CM9.0000000000001887
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