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The role of FGF21 in the pathogenesis of cardiovascular disease

The morbidity and mortality of cardiovascular diseases (CVDs) are increasing worldwide and seriously threaten human life and health. Fibroblast growth factor 21 (FGF21), a metabolic regulator, regulates glucose and lipid metabolism and may exert beneficial effects on the cardiovascular system. In re...

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Autores principales: Zhang, Ying, Liu, Dan, Long, Xiao-Xue, Fang, Qi-Chen, Jia, Wei-Ping, Li, Hua-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710326/
https://www.ncbi.nlm.nih.gov/pubmed/34939977
http://dx.doi.org/10.1097/CM9.0000000000001890
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author Zhang, Ying
Liu, Dan
Long, Xiao-Xue
Fang, Qi-Chen
Jia, Wei-Ping
Li, Hua-Ting
author_facet Zhang, Ying
Liu, Dan
Long, Xiao-Xue
Fang, Qi-Chen
Jia, Wei-Ping
Li, Hua-Ting
author_sort Zhang, Ying
collection PubMed
description The morbidity and mortality of cardiovascular diseases (CVDs) are increasing worldwide and seriously threaten human life and health. Fibroblast growth factor 21 (FGF21), a metabolic regulator, regulates glucose and lipid metabolism and may exert beneficial effects on the cardiovascular system. In recent years, FGF21 has been found to act directly on the cardiovascular system and may be used as an early biomarker of CVDs. The present review highlights the recent progress in understanding the relationship between FGF21 and CVDs including coronary heart disease, myocardial ischemia, cardiomyopathy, and heart failure and also explores the related mechanism of the cardioprotective effect of FGF21. FGF21 plays an important role in the prediction, treatment, and improvement of prognosis in CVDs. This cardioprotective effect of FGF21 may be achieved by preventing endothelial dysfunction and lipid accumulating, inhibiting cardiomyocyte apoptosis and regulating the associated oxidative stress, inflammation and autophagy. In conclusion, FGF21 is a promising target for the treatment of CVDs, however, its clinical application requires further clarification of the precise role of FGF21 in CVDs.
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spelling pubmed-87103262021-12-28 The role of FGF21 in the pathogenesis of cardiovascular disease Zhang, Ying Liu, Dan Long, Xiao-Xue Fang, Qi-Chen Jia, Wei-Ping Li, Hua-Ting Chin Med J (Engl) Review Article The morbidity and mortality of cardiovascular diseases (CVDs) are increasing worldwide and seriously threaten human life and health. Fibroblast growth factor 21 (FGF21), a metabolic regulator, regulates glucose and lipid metabolism and may exert beneficial effects on the cardiovascular system. In recent years, FGF21 has been found to act directly on the cardiovascular system and may be used as an early biomarker of CVDs. The present review highlights the recent progress in understanding the relationship between FGF21 and CVDs including coronary heart disease, myocardial ischemia, cardiomyopathy, and heart failure and also explores the related mechanism of the cardioprotective effect of FGF21. FGF21 plays an important role in the prediction, treatment, and improvement of prognosis in CVDs. This cardioprotective effect of FGF21 may be achieved by preventing endothelial dysfunction and lipid accumulating, inhibiting cardiomyocyte apoptosis and regulating the associated oxidative stress, inflammation and autophagy. In conclusion, FGF21 is a promising target for the treatment of CVDs, however, its clinical application requires further clarification of the precise role of FGF21 in CVDs. Lippincott Williams & Wilkins 2021-12-20 2021-12-08 /pmc/articles/PMC8710326/ /pubmed/34939977 http://dx.doi.org/10.1097/CM9.0000000000001890 Text en Copyright © 2021 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review Article
Zhang, Ying
Liu, Dan
Long, Xiao-Xue
Fang, Qi-Chen
Jia, Wei-Ping
Li, Hua-Ting
The role of FGF21 in the pathogenesis of cardiovascular disease
title The role of FGF21 in the pathogenesis of cardiovascular disease
title_full The role of FGF21 in the pathogenesis of cardiovascular disease
title_fullStr The role of FGF21 in the pathogenesis of cardiovascular disease
title_full_unstemmed The role of FGF21 in the pathogenesis of cardiovascular disease
title_short The role of FGF21 in the pathogenesis of cardiovascular disease
title_sort role of fgf21 in the pathogenesis of cardiovascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710326/
https://www.ncbi.nlm.nih.gov/pubmed/34939977
http://dx.doi.org/10.1097/CM9.0000000000001890
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