Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report

A 57-year-old woman with a sudden-onset seizure was hospitalized. Brain magnetic resonance imaging findings led to a suspicion of leptomeningeal carcinomatosis (LMC) without a brain parenchymal tumor, and abdominal computed tomography showed a tumor in the pancreatic tail. Endoscopic ultrasonography...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwatsuka, Kunio, Kikuta, Daiichiro, Shibuya, Hitoshi, Ogawa, Masahiro, Gotoda, Takuji, Moriyama, Mitsuhiko, Nakagawara, Hiroshi, Hemmi, Akihiro, Yamao, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710377/
https://www.ncbi.nlm.nih.gov/pubmed/34148945
http://dx.doi.org/10.2169/internalmedicine.4456-20
_version_ 1784623139143024640
author Iwatsuka, Kunio
Kikuta, Daiichiro
Shibuya, Hitoshi
Ogawa, Masahiro
Gotoda, Takuji
Moriyama, Mitsuhiko
Nakagawara, Hiroshi
Hemmi, Akihiro
Yamao, Kenji
author_facet Iwatsuka, Kunio
Kikuta, Daiichiro
Shibuya, Hitoshi
Ogawa, Masahiro
Gotoda, Takuji
Moriyama, Mitsuhiko
Nakagawara, Hiroshi
Hemmi, Akihiro
Yamao, Kenji
author_sort Iwatsuka, Kunio
collection PubMed
description A 57-year-old woman with a sudden-onset seizure was hospitalized. Brain magnetic resonance imaging findings led to a suspicion of leptomeningeal carcinomatosis (LMC) without a brain parenchymal tumor, and abdominal computed tomography showed a tumor in the pancreatic tail. Endoscopic ultrasonography-guided fine needle aspiration of the pancreatic mass revealed adenocarcinoma. Therefore, LMC from pancreatic ductal adenocarcinoma was strongly suspected. She received three courses of nab-paclitaxel plus gemcitabine and whole-brain radiation. Shortly thereafter, she developed a severe consciousness impediment and died. A pathological autopsy showed adenocarcinoma in a wide area of the leptomeninges.
format Online
Article
Text
id pubmed-8710377
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-87103772022-01-25 Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report Iwatsuka, Kunio Kikuta, Daiichiro Shibuya, Hitoshi Ogawa, Masahiro Gotoda, Takuji Moriyama, Mitsuhiko Nakagawara, Hiroshi Hemmi, Akihiro Yamao, Kenji Intern Med Case Report A 57-year-old woman with a sudden-onset seizure was hospitalized. Brain magnetic resonance imaging findings led to a suspicion of leptomeningeal carcinomatosis (LMC) without a brain parenchymal tumor, and abdominal computed tomography showed a tumor in the pancreatic tail. Endoscopic ultrasonography-guided fine needle aspiration of the pancreatic mass revealed adenocarcinoma. Therefore, LMC from pancreatic ductal adenocarcinoma was strongly suspected. She received three courses of nab-paclitaxel plus gemcitabine and whole-brain radiation. Shortly thereafter, she developed a severe consciousness impediment and died. A pathological autopsy showed adenocarcinoma in a wide area of the leptomeninges. The Japanese Society of Internal Medicine 2021-06-19 2021-12-01 /pmc/articles/PMC8710377/ /pubmed/34148945 http://dx.doi.org/10.2169/internalmedicine.4456-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Iwatsuka, Kunio
Kikuta, Daiichiro
Shibuya, Hitoshi
Ogawa, Masahiro
Gotoda, Takuji
Moriyama, Mitsuhiko
Nakagawara, Hiroshi
Hemmi, Akihiro
Yamao, Kenji
Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report
title Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report
title_full Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report
title_fullStr Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report
title_full_unstemmed Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report
title_short Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report
title_sort treatment outcome of nab-paclitaxel plus gemcitabine for leptomeningeal carcinomatosis from pancreatic ductal adenocarcinoma: an autopsy case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710377/
https://www.ncbi.nlm.nih.gov/pubmed/34148945
http://dx.doi.org/10.2169/internalmedicine.4456-20
work_keys_str_mv AT iwatsukakunio treatmentoutcomeofnabpaclitaxelplusgemcitabineforleptomeningealcarcinomatosisfrompancreaticductaladenocarcinomaanautopsycasereport
AT kikutadaiichiro treatmentoutcomeofnabpaclitaxelplusgemcitabineforleptomeningealcarcinomatosisfrompancreaticductaladenocarcinomaanautopsycasereport
AT shibuyahitoshi treatmentoutcomeofnabpaclitaxelplusgemcitabineforleptomeningealcarcinomatosisfrompancreaticductaladenocarcinomaanautopsycasereport
AT ogawamasahiro treatmentoutcomeofnabpaclitaxelplusgemcitabineforleptomeningealcarcinomatosisfrompancreaticductaladenocarcinomaanautopsycasereport
AT gotodatakuji treatmentoutcomeofnabpaclitaxelplusgemcitabineforleptomeningealcarcinomatosisfrompancreaticductaladenocarcinomaanautopsycasereport
AT moriyamamitsuhiko treatmentoutcomeofnabpaclitaxelplusgemcitabineforleptomeningealcarcinomatosisfrompancreaticductaladenocarcinomaanautopsycasereport
AT nakagawarahiroshi treatmentoutcomeofnabpaclitaxelplusgemcitabineforleptomeningealcarcinomatosisfrompancreaticductaladenocarcinomaanautopsycasereport
AT hemmiakihiro treatmentoutcomeofnabpaclitaxelplusgemcitabineforleptomeningealcarcinomatosisfrompancreaticductaladenocarcinomaanautopsycasereport
AT yamaokenji treatmentoutcomeofnabpaclitaxelplusgemcitabineforleptomeningealcarcinomatosisfrompancreaticductaladenocarcinomaanautopsycasereport

Ejemplares similares