High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy

The primary central nervous system (CNS) presentation of lymphomatoid granulomatosis (LYG) is rare, and no standard therapy for LYG with primary CNS symptoms exists. CNS-LYG patients usually survive for only less than a year from diagnosis. This is the first report of high-grade primary CNS-LYG with...

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Autores principales: Harada, Sakiko, Ando, Jun, Ando, Miki, Nitta, Hideaki, Inano, Tadaaki, Hirasawa, Yusuke, Furukawa, Yoshiki, Kinoshita, Shintaro, Kondo, Akihide, Ohshima, Koichi, Komatsu, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710380/
https://www.ncbi.nlm.nih.gov/pubmed/34121006
http://dx.doi.org/10.2169/internalmedicine.7232-21
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author Harada, Sakiko
Ando, Jun
Ando, Miki
Nitta, Hideaki
Inano, Tadaaki
Hirasawa, Yusuke
Furukawa, Yoshiki
Kinoshita, Shintaro
Kondo, Akihide
Ohshima, Koichi
Komatsu, Norio
author_facet Harada, Sakiko
Ando, Jun
Ando, Miki
Nitta, Hideaki
Inano, Tadaaki
Hirasawa, Yusuke
Furukawa, Yoshiki
Kinoshita, Shintaro
Kondo, Akihide
Ohshima, Koichi
Komatsu, Norio
author_sort Harada, Sakiko
collection PubMed
description The primary central nervous system (CNS) presentation of lymphomatoid granulomatosis (LYG) is rare, and no standard therapy for LYG with primary CNS symptoms exists. CNS-LYG patients usually survive for only less than a year from diagnosis. This is the first report of high-grade primary CNS-LYG with monoclonality that was successfully treated with rituximab monotherapy, resulting in a durable remission for more than 1 year in a 66-year-old woman with pemphigus vulgaris who was also on immunosuppressive therapy.
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spelling pubmed-87103802022-01-25 High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy Harada, Sakiko Ando, Jun Ando, Miki Nitta, Hideaki Inano, Tadaaki Hirasawa, Yusuke Furukawa, Yoshiki Kinoshita, Shintaro Kondo, Akihide Ohshima, Koichi Komatsu, Norio Intern Med Case Report The primary central nervous system (CNS) presentation of lymphomatoid granulomatosis (LYG) is rare, and no standard therapy for LYG with primary CNS symptoms exists. CNS-LYG patients usually survive for only less than a year from diagnosis. This is the first report of high-grade primary CNS-LYG with monoclonality that was successfully treated with rituximab monotherapy, resulting in a durable remission for more than 1 year in a 66-year-old woman with pemphigus vulgaris who was also on immunosuppressive therapy. The Japanese Society of Internal Medicine 2021-06-12 2021-12-01 /pmc/articles/PMC8710380/ /pubmed/34121006 http://dx.doi.org/10.2169/internalmedicine.7232-21 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Harada, Sakiko
Ando, Jun
Ando, Miki
Nitta, Hideaki
Inano, Tadaaki
Hirasawa, Yusuke
Furukawa, Yoshiki
Kinoshita, Shintaro
Kondo, Akihide
Ohshima, Koichi
Komatsu, Norio
High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy
title High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy
title_full High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy
title_fullStr High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy
title_full_unstemmed High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy
title_short High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy
title_sort high-grade primary central nervous system lymphomatoid granulomatosis: successful rituximab monotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710380/
https://www.ncbi.nlm.nih.gov/pubmed/34121006
http://dx.doi.org/10.2169/internalmedicine.7232-21
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