Cargando…

Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab

A 39-year-old man presented with peripheral eosinophilia, pulmonary eosinophilic infiltrate, and renal failure due to acute tubulointerstitial nephritis (TIN). He had experienced childhood asthma and was negative for anti-neutrophil cytoplasmic antibody (ANCA). He was tentatively diagnosed with ANCA...

Descripción completa

Detalles Bibliográficos
Autores principales: Hayama, Yuto, Tomyo, Fuminori, Ueno, Masaki, Asakawa, Shinichiro, Arai, Shigeyuki, Yamazaki, Osamu, Tamura, Yoshifuru, Mochizuki, Makoto, Ohashi, Ryuji, Shibata, Shigeru, Fujigaki, Yoshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710382/
https://www.ncbi.nlm.nih.gov/pubmed/34092738
http://dx.doi.org/10.2169/internalmedicine.7490-21
_version_ 1784623140341547008
author Hayama, Yuto
Tomyo, Fuminori
Ueno, Masaki
Asakawa, Shinichiro
Arai, Shigeyuki
Yamazaki, Osamu
Tamura, Yoshifuru
Mochizuki, Makoto
Ohashi, Ryuji
Shibata, Shigeru
Fujigaki, Yoshihide
author_facet Hayama, Yuto
Tomyo, Fuminori
Ueno, Masaki
Asakawa, Shinichiro
Arai, Shigeyuki
Yamazaki, Osamu
Tamura, Yoshifuru
Mochizuki, Makoto
Ohashi, Ryuji
Shibata, Shigeru
Fujigaki, Yoshihide
author_sort Hayama, Yuto
collection PubMed
description A 39-year-old man presented with peripheral eosinophilia, pulmonary eosinophilic infiltrate, and renal failure due to acute tubulointerstitial nephritis (TIN). He had experienced childhood asthma and was negative for anti-neutrophil cytoplasmic antibody (ANCA). He was tentatively diagnosed with ANCA-negative eosinophilic granulomatous polyangiitis (EGPA) or idiopathic hypereosinophilic syndrome (HES). Renal involvement of isolated TIN with eosinophil infiltration is rare in EGPA and HES and does not seem to have a good prognosis in the literature. However, his condition improved well with corticosteroids and mepolizumab. The revised classification of EGPA based on the etiology should dictate the proper treatment in suspected EGPA patients with nonsystemic vasculitis.
format Online
Article
Text
id pubmed-8710382
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-87103822022-01-25 Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab Hayama, Yuto Tomyo, Fuminori Ueno, Masaki Asakawa, Shinichiro Arai, Shigeyuki Yamazaki, Osamu Tamura, Yoshifuru Mochizuki, Makoto Ohashi, Ryuji Shibata, Shigeru Fujigaki, Yoshihide Intern Med Case Report A 39-year-old man presented with peripheral eosinophilia, pulmonary eosinophilic infiltrate, and renal failure due to acute tubulointerstitial nephritis (TIN). He had experienced childhood asthma and was negative for anti-neutrophil cytoplasmic antibody (ANCA). He was tentatively diagnosed with ANCA-negative eosinophilic granulomatous polyangiitis (EGPA) or idiopathic hypereosinophilic syndrome (HES). Renal involvement of isolated TIN with eosinophil infiltration is rare in EGPA and HES and does not seem to have a good prognosis in the literature. However, his condition improved well with corticosteroids and mepolizumab. The revised classification of EGPA based on the etiology should dictate the proper treatment in suspected EGPA patients with nonsystemic vasculitis. The Japanese Society of Internal Medicine 2021-06-05 2021-12-01 /pmc/articles/PMC8710382/ /pubmed/34092738 http://dx.doi.org/10.2169/internalmedicine.7490-21 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hayama, Yuto
Tomyo, Fuminori
Ueno, Masaki
Asakawa, Shinichiro
Arai, Shigeyuki
Yamazaki, Osamu
Tamura, Yoshifuru
Mochizuki, Makoto
Ohashi, Ryuji
Shibata, Shigeru
Fujigaki, Yoshihide
Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab
title Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab
title_full Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab
title_fullStr Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab
title_full_unstemmed Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab
title_short Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab
title_sort renal involvement as rare acute tubulointerstitial nephritis in a patient with eosinophilic disorder treated with early add-on administration of mepolizumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710382/
https://www.ncbi.nlm.nih.gov/pubmed/34092738
http://dx.doi.org/10.2169/internalmedicine.7490-21
work_keys_str_mv AT hayamayuto renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT tomyofuminori renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT uenomasaki renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT asakawashinichiro renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT araishigeyuki renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT yamazakiosamu renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT tamurayoshifuru renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT mochizukimakoto renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT ohashiryuji renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT shibatashigeru renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab
AT fujigakiyoshihide renalinvolvementasrareacutetubulointerstitialnephritisinapatientwitheosinophilicdisordertreatedwithearlyaddonadministrationofmepolizumab