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Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab
A 39-year-old man presented with peripheral eosinophilia, pulmonary eosinophilic infiltrate, and renal failure due to acute tubulointerstitial nephritis (TIN). He had experienced childhood asthma and was negative for anti-neutrophil cytoplasmic antibody (ANCA). He was tentatively diagnosed with ANCA...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Internal Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710382/ https://www.ncbi.nlm.nih.gov/pubmed/34092738 http://dx.doi.org/10.2169/internalmedicine.7490-21 |
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author | Hayama, Yuto Tomyo, Fuminori Ueno, Masaki Asakawa, Shinichiro Arai, Shigeyuki Yamazaki, Osamu Tamura, Yoshifuru Mochizuki, Makoto Ohashi, Ryuji Shibata, Shigeru Fujigaki, Yoshihide |
author_facet | Hayama, Yuto Tomyo, Fuminori Ueno, Masaki Asakawa, Shinichiro Arai, Shigeyuki Yamazaki, Osamu Tamura, Yoshifuru Mochizuki, Makoto Ohashi, Ryuji Shibata, Shigeru Fujigaki, Yoshihide |
author_sort | Hayama, Yuto |
collection | PubMed |
description | A 39-year-old man presented with peripheral eosinophilia, pulmonary eosinophilic infiltrate, and renal failure due to acute tubulointerstitial nephritis (TIN). He had experienced childhood asthma and was negative for anti-neutrophil cytoplasmic antibody (ANCA). He was tentatively diagnosed with ANCA-negative eosinophilic granulomatous polyangiitis (EGPA) or idiopathic hypereosinophilic syndrome (HES). Renal involvement of isolated TIN with eosinophil infiltration is rare in EGPA and HES and does not seem to have a good prognosis in the literature. However, his condition improved well with corticosteroids and mepolizumab. The revised classification of EGPA based on the etiology should dictate the proper treatment in suspected EGPA patients with nonsystemic vasculitis. |
format | Online Article Text |
id | pubmed-8710382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-87103822022-01-25 Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab Hayama, Yuto Tomyo, Fuminori Ueno, Masaki Asakawa, Shinichiro Arai, Shigeyuki Yamazaki, Osamu Tamura, Yoshifuru Mochizuki, Makoto Ohashi, Ryuji Shibata, Shigeru Fujigaki, Yoshihide Intern Med Case Report A 39-year-old man presented with peripheral eosinophilia, pulmonary eosinophilic infiltrate, and renal failure due to acute tubulointerstitial nephritis (TIN). He had experienced childhood asthma and was negative for anti-neutrophil cytoplasmic antibody (ANCA). He was tentatively diagnosed with ANCA-negative eosinophilic granulomatous polyangiitis (EGPA) or idiopathic hypereosinophilic syndrome (HES). Renal involvement of isolated TIN with eosinophil infiltration is rare in EGPA and HES and does not seem to have a good prognosis in the literature. However, his condition improved well with corticosteroids and mepolizumab. The revised classification of EGPA based on the etiology should dictate the proper treatment in suspected EGPA patients with nonsystemic vasculitis. The Japanese Society of Internal Medicine 2021-06-05 2021-12-01 /pmc/articles/PMC8710382/ /pubmed/34092738 http://dx.doi.org/10.2169/internalmedicine.7490-21 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Hayama, Yuto Tomyo, Fuminori Ueno, Masaki Asakawa, Shinichiro Arai, Shigeyuki Yamazaki, Osamu Tamura, Yoshifuru Mochizuki, Makoto Ohashi, Ryuji Shibata, Shigeru Fujigaki, Yoshihide Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab |
title | Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab |
title_full | Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab |
title_fullStr | Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab |
title_full_unstemmed | Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab |
title_short | Renal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab |
title_sort | renal involvement as rare acute tubulointerstitial nephritis in a patient with eosinophilic disorder treated with early add-on administration of mepolizumab |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710382/ https://www.ncbi.nlm.nih.gov/pubmed/34092738 http://dx.doi.org/10.2169/internalmedicine.7490-21 |
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