Altered H3 histone acetylation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7

A common mechanism in inherited ataxia is a vulnerability of DNA damage. Spinocerebellar ataxia type 7 (SCA7) is a CAG-polyglutamine-repeat disorder characterized by cerebellar and retinal degeneration. Polyglutamine-expanded ataxin-7 protein incorporates into STAGA co-activator complex and interfer...

Descripción completa

Detalles Bibliográficos
Autores principales: Switonski, Pawel M., Delaney, Joe R., Bartelt, Luke C., Niu, Chenchen, Ramos-Zapatero, Maria, Spann, Nathanael J., Alaghatta, Akshay, Chen, Toby, Griffin, Emily N., Bapat, Jaidev, Sopher, Bryce L., La Spada, Albert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710427/
https://www.ncbi.nlm.nih.gov/pubmed/34852229
http://dx.doi.org/10.1016/j.celrep.2021.110062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710427/
https://www.ncbi.nlm.nih.gov/pubmed/34852229
http://dx.doi.org/10.1016/j.celrep.2021.110062

Ejemplares similares