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Altered H3 histone acetylation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7

A common mechanism in inherited ataxia is a vulnerability of DNA damage. Spinocerebellar ataxia type 7 (SCA7) is a CAG-polyglutamine-repeat disorder characterized by cerebellar and retinal degeneration. Polyglutamine-expanded ataxin-7 protein incorporates into STAGA co-activator complex and interfer...

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Detalles Bibliográficos
Autores principales:	Switonski, Pawel M., Delaney, Joe R., Bartelt, Luke C., Niu, Chenchen, Ramos-Zapatero, Maria, Spann, Nathanael J., Alaghatta, Akshay, Chen, Toby, Griffin, Emily N., Bapat, Jaidev, Sopher, Bryce L., La Spada, Albert R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710427/ https://www.ncbi.nlm.nih.gov/pubmed/34852229 http://dx.doi.org/10.1016/j.celrep.2021.110062

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