Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models

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Amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) is a fatal neurodegenerative disorder, and continued innovation is needed for improved understanding and for developing therapeutics. We have created next-generation genomically humanized knockin mouse models, by replacing the mouse gen...

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Detalles Bibliográficos
Autores principales: Devoy, Anny, Price, Georgia, De Giorgio, Francesca, Bunton-Stasyshyn, Rosie, Thompson, David, Gasco, Samanta, Allan, Alasdair, Codner, Gemma F., Nair, Remya R., Tibbit, Charlotte, McLeod, Ross, Ali, Zeinab, Noda, Judith, Marrero-Gagliardi, Alessandro, Brito-Armas, José M., Williams, Chloe, Öztürk, Muhammet M., Simon, Michelle, O'Neill, Edward, Bryce-Smith, Sam, Harrison, Jackie, Atkins, Gemma, Corrochano, Silvia, Stewart, Michelle, Gilthorpe, Jonathan D., Teboul, Lydia, Acevedo-Arozena, Abraham, Fisher, Elizabeth M.C., Cunningham, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710557/
https://www.ncbi.nlm.nih.gov/pubmed/34988393
http://dx.doi.org/10.1016/j.isci.2021.103463
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