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Influence of Prebiotic Activity of Agave salmiana Fructans on Mucus Production and Morphology Changes in Colonic Epithelium Cell of Healthy Wistar Rats

The beneficial health of evaluating prebiotic effect by the consumption of Agave salmiana fructans (A. salmiana fructans) was assessed in the epithelium of the cecum and proximal colon of Wistar rats fed at different doses for 35 days with regards to mucus production, morphological cell changes, and...

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Autores principales: Castillo Andrade, Amneris Iraida, García Chávez, Erika, Rivera Bautista, Cecilia, Oros Ovalle, Cuauhtemoc, Ruiz Cabrera, Miguel Angel, Grajales Lagunes, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710659/
https://www.ncbi.nlm.nih.gov/pubmed/34966396
http://dx.doi.org/10.3389/fpls.2021.717460
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author Castillo Andrade, Amneris Iraida
García Chávez, Erika
Rivera Bautista, Cecilia
Oros Ovalle, Cuauhtemoc
Ruiz Cabrera, Miguel Angel
Grajales Lagunes, Alicia
author_facet Castillo Andrade, Amneris Iraida
García Chávez, Erika
Rivera Bautista, Cecilia
Oros Ovalle, Cuauhtemoc
Ruiz Cabrera, Miguel Angel
Grajales Lagunes, Alicia
author_sort Castillo Andrade, Amneris Iraida
collection PubMed
description The beneficial health of evaluating prebiotic effect by the consumption of Agave salmiana fructans (A. salmiana fructans) was assessed in the epithelium of the cecum and proximal colon of Wistar rats fed at different doses for 35 days with regards to mucus production, morphological cell changes, and the serum concentration of tumor necrosis factor-α (TNF-α). Results showed a significant increase in mucus-secreting cells (P < 0.05) and a normal structure with preserved crypts, without morphological damage to colonic cells for a dose of 12.5% (w/w) with respect to the control and the other doses evaluated. The concentration of pro-inflammatory cytokine TNF-α was decreased significantly (P < 0.05) in the groups with doses of 10 and 12.5% (w/w) at 7 and 35 days, respectively. This effect was positively correlated with the reduction of inflammation in epithelial cells. This study provides direct evidence of the effects of the A. salmiana fructans on the colonic epithelium, demonstrating that a diet supplemented with 12.5% of fructans for 35 days exerts health benefits through the strengthening of the mucosa layer, which favors the adherence of the bacterial population and suppresses inflammation.
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spelling pubmed-87106592021-12-28 Influence of Prebiotic Activity of Agave salmiana Fructans on Mucus Production and Morphology Changes in Colonic Epithelium Cell of Healthy Wistar Rats Castillo Andrade, Amneris Iraida García Chávez, Erika Rivera Bautista, Cecilia Oros Ovalle, Cuauhtemoc Ruiz Cabrera, Miguel Angel Grajales Lagunes, Alicia Front Plant Sci Plant Science The beneficial health of evaluating prebiotic effect by the consumption of Agave salmiana fructans (A. salmiana fructans) was assessed in the epithelium of the cecum and proximal colon of Wistar rats fed at different doses for 35 days with regards to mucus production, morphological cell changes, and the serum concentration of tumor necrosis factor-α (TNF-α). Results showed a significant increase in mucus-secreting cells (P < 0.05) and a normal structure with preserved crypts, without morphological damage to colonic cells for a dose of 12.5% (w/w) with respect to the control and the other doses evaluated. The concentration of pro-inflammatory cytokine TNF-α was decreased significantly (P < 0.05) in the groups with doses of 10 and 12.5% (w/w) at 7 and 35 days, respectively. This effect was positively correlated with the reduction of inflammation in epithelial cells. This study provides direct evidence of the effects of the A. salmiana fructans on the colonic epithelium, demonstrating that a diet supplemented with 12.5% of fructans for 35 days exerts health benefits through the strengthening of the mucosa layer, which favors the adherence of the bacterial population and suppresses inflammation. Frontiers Media S.A. 2021-12-13 /pmc/articles/PMC8710659/ /pubmed/34966396 http://dx.doi.org/10.3389/fpls.2021.717460 Text en Copyright © 2021 Castillo Andrade, García Chávez, Rivera Bautista, Oros Ovalle, Ruiz Cabrera and Grajales Lagunes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Castillo Andrade, Amneris Iraida
García Chávez, Erika
Rivera Bautista, Cecilia
Oros Ovalle, Cuauhtemoc
Ruiz Cabrera, Miguel Angel
Grajales Lagunes, Alicia
Influence of Prebiotic Activity of Agave salmiana Fructans on Mucus Production and Morphology Changes in Colonic Epithelium Cell of Healthy Wistar Rats
title Influence of Prebiotic Activity of Agave salmiana Fructans on Mucus Production and Morphology Changes in Colonic Epithelium Cell of Healthy Wistar Rats
title_full Influence of Prebiotic Activity of Agave salmiana Fructans on Mucus Production and Morphology Changes in Colonic Epithelium Cell of Healthy Wistar Rats
title_fullStr Influence of Prebiotic Activity of Agave salmiana Fructans on Mucus Production and Morphology Changes in Colonic Epithelium Cell of Healthy Wistar Rats
title_full_unstemmed Influence of Prebiotic Activity of Agave salmiana Fructans on Mucus Production and Morphology Changes in Colonic Epithelium Cell of Healthy Wistar Rats
title_short Influence of Prebiotic Activity of Agave salmiana Fructans on Mucus Production and Morphology Changes in Colonic Epithelium Cell of Healthy Wistar Rats
title_sort influence of prebiotic activity of agave salmiana fructans on mucus production and morphology changes in colonic epithelium cell of healthy wistar rats
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710659/
https://www.ncbi.nlm.nih.gov/pubmed/34966396
http://dx.doi.org/10.3389/fpls.2021.717460
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