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Assessment of Alveolar Bone and Periodontal Status in Peritoneal Dialysis Patients

Chronic kidney disease (CKD) affects 8–13% of the global population and has become one of the largest burdens on healthcare systems around the world. Peritoneal dialysis is one of the ultimate treatments for patients with severe CKD. Recently, increasing severe periodontal problems have been found i...

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Autores principales: Sun, Kristine, Shen, Hui, Liu, Yingli, Deng, Hai, Chen, Huiwen, Song, Zhongchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710660/
https://www.ncbi.nlm.nih.gov/pubmed/34966288
http://dx.doi.org/10.3389/fphys.2021.759056
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author Sun, Kristine
Shen, Hui
Liu, Yingli
Deng, Hai
Chen, Huiwen
Song, Zhongchen
author_facet Sun, Kristine
Shen, Hui
Liu, Yingli
Deng, Hai
Chen, Huiwen
Song, Zhongchen
author_sort Sun, Kristine
collection PubMed
description Chronic kidney disease (CKD) affects 8–13% of the global population and has become one of the largest burdens on healthcare systems around the world. Peritoneal dialysis is one of the ultimate treatments for patients with severe CKD. Recently, increasing severe periodontal problems have been found in CKD patients. Periodontitis has been identified as a new variable risk factor for CKD. The aim of this study was to investigate the periodontal status and severity of alveolar bone loss in CKD patients with peritoneal dialysis (PD). One hundred and six patients undergoing PD (PD group) and 97 systemically healthy periodontitis patients (control group) were enrolled. The differences in the dimensions of the alveolar bone between two groups were compared, and the distribution of alveolar bone defects was analyzed by cone-beam computed tomography (CBCT). Gingival index (GI), plaque index (PLI), periodontal probing depth (PPD), and attachment loss (AL) were recorded. The levels of inflammatory factors in gingival crevicular fluid were assessed by ELISA. Compared to control group, there was a higher degree of alveolar bone loss in maxillary premolars, maxillary 2nd molar and mandibular 1st molar in patients with PD (p < 0.05). A comparison of bone loss in different sites revealed that the area with the highest degree of bone loss were on the mesial-buccal, mid-buccal, distal-buccal, and mesial-lingual site in PD patients. The expression levels of inflammatory factors were higher in PD group (p < 0.01). In conclusion, PD patients presented more severe periodontal and inflammatory status than systemically healthy periodontitis patients. The loss of the alveolar bone differed between the two groups. Different sites and teeth exhibited a diverse degree of bone loss. This study highlights that clinicians should pay close attention to periodontal status of peritoneal dialysis patients and provides a new thinking to improve healthcare for CKD.
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spelling pubmed-87106602021-12-28 Assessment of Alveolar Bone and Periodontal Status in Peritoneal Dialysis Patients Sun, Kristine Shen, Hui Liu, Yingli Deng, Hai Chen, Huiwen Song, Zhongchen Front Physiol Physiology Chronic kidney disease (CKD) affects 8–13% of the global population and has become one of the largest burdens on healthcare systems around the world. Peritoneal dialysis is one of the ultimate treatments for patients with severe CKD. Recently, increasing severe periodontal problems have been found in CKD patients. Periodontitis has been identified as a new variable risk factor for CKD. The aim of this study was to investigate the periodontal status and severity of alveolar bone loss in CKD patients with peritoneal dialysis (PD). One hundred and six patients undergoing PD (PD group) and 97 systemically healthy periodontitis patients (control group) were enrolled. The differences in the dimensions of the alveolar bone between two groups were compared, and the distribution of alveolar bone defects was analyzed by cone-beam computed tomography (CBCT). Gingival index (GI), plaque index (PLI), periodontal probing depth (PPD), and attachment loss (AL) were recorded. The levels of inflammatory factors in gingival crevicular fluid were assessed by ELISA. Compared to control group, there was a higher degree of alveolar bone loss in maxillary premolars, maxillary 2nd molar and mandibular 1st molar in patients with PD (p < 0.05). A comparison of bone loss in different sites revealed that the area with the highest degree of bone loss were on the mesial-buccal, mid-buccal, distal-buccal, and mesial-lingual site in PD patients. The expression levels of inflammatory factors were higher in PD group (p < 0.01). In conclusion, PD patients presented more severe periodontal and inflammatory status than systemically healthy periodontitis patients. The loss of the alveolar bone differed between the two groups. Different sites and teeth exhibited a diverse degree of bone loss. This study highlights that clinicians should pay close attention to periodontal status of peritoneal dialysis patients and provides a new thinking to improve healthcare for CKD. Frontiers Media S.A. 2021-12-13 /pmc/articles/PMC8710660/ /pubmed/34966288 http://dx.doi.org/10.3389/fphys.2021.759056 Text en Copyright © 2021 Sun, Shen, Liu, Deng, Chen and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Sun, Kristine
Shen, Hui
Liu, Yingli
Deng, Hai
Chen, Huiwen
Song, Zhongchen
Assessment of Alveolar Bone and Periodontal Status in Peritoneal Dialysis Patients
title Assessment of Alveolar Bone and Periodontal Status in Peritoneal Dialysis Patients
title_full Assessment of Alveolar Bone and Periodontal Status in Peritoneal Dialysis Patients
title_fullStr Assessment of Alveolar Bone and Periodontal Status in Peritoneal Dialysis Patients
title_full_unstemmed Assessment of Alveolar Bone and Periodontal Status in Peritoneal Dialysis Patients
title_short Assessment of Alveolar Bone and Periodontal Status in Peritoneal Dialysis Patients
title_sort assessment of alveolar bone and periodontal status in peritoneal dialysis patients
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710660/
https://www.ncbi.nlm.nih.gov/pubmed/34966288
http://dx.doi.org/10.3389/fphys.2021.759056
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