Cargando…

Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells Via PKM2 Phosphorylation

BACKGROUND: Aerobic glycolysis is a hallmark of glucose metabolism in cancer. Previous studies have suggested that cancer cell–derived extracellular vesicles (EVs) can modulate glucose metabolism in adjacent cells and promote disease progression. We hypothesized that EVs originating from cancer cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Seo Young, Lee, Eun Ji, Byun, Jung Woo, Han, Dohyun, Choi, Yoori, Hwang, Do Won, Lee, Dong Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710663/ https://www.ncbi.nlm.nih.gov/pubmed/34966685 http://dx.doi.org/10.3389/fonc.2021.785450

Ejemplares similares

Human neural stem cell-derived extracellular vesicles protect against Parkinson’s disease pathologies
por: Lee, Eun Ji, et al.
Publicado: (2022)

Extracellular Vesicles in Luminal Fluid of the Ovine Uterus
por: Burns, Gregory, et al.
Publicado: (2014)

Microdomains form on the luminal face of neuronal extracellular vesicle membranes
por: Matthies, Doreen, et al.
Publicado: (2020)

Effects of osteoblast-derived extracellular vesicles on aggressiveness, redox status and mitochondrial bioenergetics of MNNG/HOS osteosarcoma cells
por: Ponzetti, Marco, et al.
Publicado: (2022)

Extracellular Hsp90α Supports the ePKM2-GRP78-AKT Axis to Promote Tumor Metastasis
por: Zhang, Shaosen, et al.
Publicado: (2022)

NEK2 Promotes Cell Proliferation and Glycolysis by Regulating PKM2 Abundance via Phosphorylation in Diffuse Large B-Cell Lymphoma
por: Zhou, Lingna, et al.
Publicado: (2021)

Fecal Microbiota and Gut Microbe-Derived Extracellular Vesicles in Colorectal Cancer
por: Park, Jihye, et al.
Publicado: (2021)

Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers
por: Soundararajan, Rama, et al.
Publicado: (2018)

Monitoring of single extracellular vesicle heterogeneity in cancer progression and therapy
por: Lee, Yoon-Jin, et al.
Publicado: (2023)

Cyclooxygenase-2 Upregulated by Temozolomide in Glioblastoma Cells Is Shuttled In Extracellular Vesicles Modifying Recipient Cell Phenotype
por: Lombardi, Francesca, et al.
Publicado: (2022)

The Emerging Roles of Extracellular Vesicles in Osteosarcoma
por: Perut, Francesca, et al.
Publicado: (2019)

Editorial: Extracellular Vesicles in Bone Oncology
por: Perut, Francesca, et al.
Publicado: (2022)

Editorial: Extracellular vesicles in gastrointestinal cancers
por: Li, Liang, et al.
Publicado: (2023)

Unusual phylogenetic tree and circulating actionable ESR1 mutations in an aggressive luminal/HER2-low breast cancer: Case report
por: Allegretti, Matteo, et al.
Publicado: (2023)

Alpha-2-macroglobulin as a novel diagnostic biomarker for human bladder cancer in urinary extracellular vesicles
por: Lee, Jisu, et al.
Publicado: (2022)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

Extracellular Vesicles and Chemotherapy Resistance in the AML Microenvironment
por: Nehrbas, Jill, et al.
Publicado: (2020)

Extracellular Vesicles: An Emerging Nanoplatform for Cancer Therapy
por: Ma, Yifan, et al.
Publicado: (2021)

Extracellular Vesicles and Hepatocellular Carcinoma: Opportunities and Challenges
por: Wang, Juan, et al.
Publicado: (2022)

Emerging diversity in extracellular vesicles and their roles in cancer
por: Sohal, Ikjot S., et al.
Publicado: (2023)

Potential Role of Exercise Induced Extracellular Vesicles in Prostate Cancer Suppression
por: Zhang, Ying, et al.
Publicado: (2021)

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
por: Zahra, Kulsoom, et al.
Publicado: (2020)

AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth
por: Park, Young Soo, et al.
Publicado: (2016)

Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation
por: Hong, Linjun, et al.
Publicado: (2023)

Extracellular Vesicles in Prostate Cancer Carcinogenesis, Diagnosis, and Management
por: Vlaeminck-Guillem, Virginie
Publicado: (2018)

Circulating Extracellular Vesicles in Gynecological Tumors: Realities and Challenges
por: Herrero, Carolina, et al.
Publicado: (2020)

Impact of Chemotherapy on Extracellular Vesicles: Understanding the Chemo-EVs
por: Ab Razak, Nur' Syahada, et al.
Publicado: (2019)

Extracellular Vesicles and the Inflammasome: An Intricate Network Sustaining Chemoresistance
por: Mezzasoma, Letizia, et al.
Publicado: (2022)

The role and application of small extracellular vesicles in breast cancer
por: Yi, Xiaomei, et al.
Publicado: (2022)

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
por: Li, Tong, et al.
Publicado: (2019)

Development and validation of an ultrasound-based radiomics nomogram for predicting the luminal from non-luminal type in patients with breast carcinoma
por: Wu, Jiangfeng, et al.
Publicado: (2022)

Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs
por: Zocco, Davide, et al.
Publicado: (2014)

Exploring Small Extracellular Vesicles for Precision Medicine in Prostate Cancer
por: Giulietti, Matteo, et al.
Publicado: (2018)

Extracellular Vesicles As Modulators of Tumor Microenvironment and Disease Progression in Glioma
por: Mondal, Abir, et al.
Publicado: (2017)

Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies
por: Gargiulo, Ernesto, et al.
Publicado: (2020)

Small Extracellular Vesicles: A Novel Avenue for Cancer Management
por: Gao, Yanan, et al.
Publicado: (2021)

Role of Extracellular Vesicles on Cancer Lymphangiogenesis and Lymph Node Metastasis
por: Wang, Linlin, et al.
Publicado: (2021)

The history of small extracellular vesicles and their implication in cancer drug resistance
por: Palazzolo, Stefano, et al.
Publicado: (2022)

Editorial: Understanding the RNA Species in the Extracellular Vesicles of Multiple Myeloma
por: Chen, Maoshan, et al.
Publicado: (2022)

Application of engineered extracellular vesicles to overcome drug resistance in cancer
por: Nonaka, Taichiro
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_co6p5mo8q9eoa3nm61rcsif83n