Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication

All tumors have DNA mutations, and a predictive understanding of those mutations could inform clinical treatments. However, 40% of the mutations are variants of unknown significance (VUS), with the challenge being to objectively predict whether a VUS is pathogenic and supports the tumor or whether i...

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Detalles Bibliográficos
Autores principales: Tsutakawa, Susan E., Bacolla, Albino, Katsonis, Panagiotis, Bralić, Amer, Hamdan, Samir M., Lichtarge, Olivier, Tainer, John A., Tsai, Chi-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710748/
https://www.ncbi.nlm.nih.gov/pubmed/34966786
http://dx.doi.org/10.3389/fmolb.2021.791792

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