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A mechanism-based proof of concept study on the effects of duloxetine in patients with painful knee osteoarthritis

BACKGROUND: The global burden of osteoarthritis (OA) is steadily increasing due to demographic and lifestyle changes. The nervous system can undergo peripheral and central neuroplastic changes (sensitization) in patients with OA impacting the options to manage the pain adequately. As a result of sen...

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Detalles Bibliográficos
Autores principales:	Ammitzbøll, Nadia, Arendt-Nielsen, Lars, Bertoli, Davide, Brock, Christina, Olesen, Anne Estrup, Kappel, Andreas, Drewes, Asbjørn Mohr, Petersen, Kristian Kjær
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710922/ https://www.ncbi.nlm.nih.gov/pubmed/34961547 http://dx.doi.org/10.1186/s13063-021-05941-y

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