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Care management and 90-day mortality in patients hospitalized for myocardial infarction and COVID-19 in France
BACKGROUND: Concomitant COVID-19 in patients with myocardial infarction (MI) may lead to difficulties in acute care management and may impair prognosis. To date, studies have involved a limited number of patients. PURPOSE: To estimate and compare the characteristics, care management and 90-day outco...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Masson SAS
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710960/ http://dx.doi.org/10.1016/j.acvdsp.2021.09.005 |
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author | Grave, C. Gabet, A. Empana, J.P. Puymirat, E. Tuppin, P. Danchin, N. Olié, V. |
author_facet | Grave, C. Gabet, A. Empana, J.P. Puymirat, E. Tuppin, P. Danchin, N. Olié, V. |
author_sort | Grave, C. |
collection | PubMed |
description | BACKGROUND: Concomitant COVID-19 in patients with myocardial infarction (MI) may lead to difficulties in acute care management and may impair prognosis. To date, studies have involved a limited number of patients. PURPOSE: To estimate and compare the characteristics, care management and 90-day outcomes of patients hospitalized for MI who didn’t have Covid-19, with those having concomitant hospital diagnosis of Covid-19 from the French National Health Data System, an exhaustive and nationwide database. METHODS: All patients hospitalised for MI in France between 30 December 2019 and 4 October 2020 were included. Patients with a previous hospitalization with Covid-19 were excluded (n = 135). Patients’ characteristics were compared according to Covid-19 status. 90-day mortality rates and follow-up outcomes were estimated and adjusted on age, sex and comorbidities. RESULTS: Among the 55,389 patients hospitalized for MI, 329 had concomitant Covid-19 (21% asymptomatic). MI patients with concomitant Covid-19 were more comorbid than patients without Covid-19. They had longer hospital stays, more admissions to resuscitation unit, underwent less percutaneous coronary intervention, and discharged more often to rehabilitation units than patients without Covid-19. The in-hospital and 90-day-out-of hospital mortality rates of MI patients with Covid-19 were 11.9% and 6.2%, respectively, compared to 3.5% and 2.8% in MI patients without Covid-19. The risk of in-hospital and out-of-hospital death remained increased after adjustment on comorbidities (OR(aj)(in-hosp) = 3.31[2.32;4.72], OR(aj)(out-of-hosp) = 1.79 [1.02;3.15]). CONCLUSIONS: The prognosis of patients hospitalized for MI who had concomitant Covid-19 was impaired in the short term but also in the medium term. These results underline the need of an urgent protection of the population at cardiovascular risk from Covid-19, as well as a systematized and rapid management despite the pandemic context, and then a close follow-up of these patients. |
format | Online Article Text |
id | pubmed-8710960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Published by Elsevier Masson SAS |
record_format | MEDLINE/PubMed |
spelling | pubmed-87109602021-12-28 Care management and 90-day mortality in patients hospitalized for myocardial infarction and COVID-19 in France Grave, C. Gabet, A. Empana, J.P. Puymirat, E. Tuppin, P. Danchin, N. Olié, V. Archives of Cardiovascular Diseases. Supplements 297 BACKGROUND: Concomitant COVID-19 in patients with myocardial infarction (MI) may lead to difficulties in acute care management and may impair prognosis. To date, studies have involved a limited number of patients. PURPOSE: To estimate and compare the characteristics, care management and 90-day outcomes of patients hospitalized for MI who didn’t have Covid-19, with those having concomitant hospital diagnosis of Covid-19 from the French National Health Data System, an exhaustive and nationwide database. METHODS: All patients hospitalised for MI in France between 30 December 2019 and 4 October 2020 were included. Patients with a previous hospitalization with Covid-19 were excluded (n = 135). Patients’ characteristics were compared according to Covid-19 status. 90-day mortality rates and follow-up outcomes were estimated and adjusted on age, sex and comorbidities. RESULTS: Among the 55,389 patients hospitalized for MI, 329 had concomitant Covid-19 (21% asymptomatic). MI patients with concomitant Covid-19 were more comorbid than patients without Covid-19. They had longer hospital stays, more admissions to resuscitation unit, underwent less percutaneous coronary intervention, and discharged more often to rehabilitation units than patients without Covid-19. The in-hospital and 90-day-out-of hospital mortality rates of MI patients with Covid-19 were 11.9% and 6.2%, respectively, compared to 3.5% and 2.8% in MI patients without Covid-19. The risk of in-hospital and out-of-hospital death remained increased after adjustment on comorbidities (OR(aj)(in-hosp) = 3.31[2.32;4.72], OR(aj)(out-of-hosp) = 1.79 [1.02;3.15]). CONCLUSIONS: The prognosis of patients hospitalized for MI who had concomitant Covid-19 was impaired in the short term but also in the medium term. These results underline the need of an urgent protection of the population at cardiovascular risk from Covid-19, as well as a systematized and rapid management despite the pandemic context, and then a close follow-up of these patients. Published by Elsevier Masson SAS 2022-01 2021-12-27 /pmc/articles/PMC8710960/ http://dx.doi.org/10.1016/j.acvdsp.2021.09.005 Text en Copyright © 2021 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | 297 Grave, C. Gabet, A. Empana, J.P. Puymirat, E. Tuppin, P. Danchin, N. Olié, V. Care management and 90-day mortality in patients hospitalized for myocardial infarction and COVID-19 in France |
title | Care management and 90-day mortality in patients hospitalized for myocardial infarction and COVID-19 in France |
title_full | Care management and 90-day mortality in patients hospitalized for myocardial infarction and COVID-19 in France |
title_fullStr | Care management and 90-day mortality in patients hospitalized for myocardial infarction and COVID-19 in France |
title_full_unstemmed | Care management and 90-day mortality in patients hospitalized for myocardial infarction and COVID-19 in France |
title_short | Care management and 90-day mortality in patients hospitalized for myocardial infarction and COVID-19 in France |
title_sort | care management and 90-day mortality in patients hospitalized for myocardial infarction and covid-19 in france |
topic | 297 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710960/ http://dx.doi.org/10.1016/j.acvdsp.2021.09.005 |
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