Left ventricular global longitudinal strain alteration in young patient and correlation with post-COVID syndrome (TUN END COV Study)

BACKGROUND: Several protocols are in study to understand mechanisms of these persistent symptoms of COVID-19. The conventional echocardiography can be a good tool to detect abnormalities in the cardiovascular system induced by long COVID-19. OBJECTIVE: Correlation between echocardiographic parameters and symptoms of long COVID and the spontaneous evolution at one month of follow-up. PATIENTS AND METHODS: A prospective multicentric study including a total of 630 patients diagnosed with COVID-19, 2 weeks to one month after recovering from COVID-19. Young patients without any medical history other than recent SARS-CoV2 infection are selected. A meticulous interrogation and clinical examination as well as an echocardiography are performed in all of patients. In addition to symptoms, we assessed echocardiographic parameters including initial left ventricular global longitudinal strain (initial SLG: SLGi) and after one month (SLG control: SLGc). RESULTS: Mean SLGi was −18.1 ± 2.4 in study group (−19.6 ± 1.5; P < 0.001). Forty-two patients (52.5%) had initially altered strain versus 38 patients (47.5%) with normal strain. The threshold value for SLG in our study has been established using ROC curve which was −17.95% with sensibility (52.5%) and specificity (83.7%). we found a statistically significative correlation between the initial alteration of SLG and persistent symptoms in multivariate test: dyspnea (P < 0.002); chest pain (P = 0.031). At one month of follow-up, 87.5% of patients improved their SLG. And there was a correlation between control GS value (mean SLGc was −18.91 ± 3.33; P = 0.002) associated with a marked improvement in symptoms (P = 0.001). CONCLUSION: We reported here an original case series of SLG alteration induced by SARS-CoV2 infection that is correlated with the presence of chest pain and dyspnea. However, this affection seems to be spontaneously significantly reversible and associated with significant clinical improvement.