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Transient endothelial injury and release of lupus anticoagulant in COVID-19
INTRODUCTION: Coronavirus disease 2019 (COVID-19) has been described as an endothelial disease associated with a procoagulant state and a high prevalence of lupus anticoagulant (LA). No study has so far evaluated the persistence of endothelial injury after recovery. PURPOSE: We report the results of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Masson SAS
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710966/ http://dx.doi.org/10.1016/j.acvdsp.2021.10.002 |
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author | Trimaille, A. Marchandot, B. Oulehri, W. Carmona, A. Vollmer, O. Poindron, V. Matsushita, K. Sattler, L. Grunebaum, L. Korganow, A. Schini-Kerth, V. Morel, O. |
author_facet | Trimaille, A. Marchandot, B. Oulehri, W. Carmona, A. Vollmer, O. Poindron, V. Matsushita, K. Sattler, L. Grunebaum, L. Korganow, A. Schini-Kerth, V. Morel, O. |
author_sort | Trimaille, A. |
collection | PubMed |
description | INTRODUCTION: Coronavirus disease 2019 (COVID-19) has been described as an endothelial disease associated with a procoagulant state and a high prevalence of lupus anticoagulant (LA). No study has so far evaluated the persistence of endothelial injury after recovery. PURPOSE: We report the results of a systematic biologic assessment more than 12 weeks after the acute phase of COVID-19. METHODS: Patients hospitalized for COVID-19 at Strasbourg university hospital, France, and tested positive for LA were included in the microparticles in COVID-19 (MICO) study. During the prospective follow-up, blood samples were obtained at least 12 weeks after COVID-19 diagnosis. RESULTS: Between March 3 and May 5, 2020, 56 COVID-19 patients with positive LA were included in the study. Five patients were excluded from the analysis because of direct oral anticoagulant treatment at the time of follow-up. A total of 51 patients were included in the final analysis. The mean age was 61 years. During the acute phase of COVID-19, 38 patients (74.5%) required mechanical ventilation, 10 patients (19.7%) presented a venous thrombotic event and mean von Willebrand factor antigen (vWF:Ag) level was 409.5%. Follow-up visit was performed at a median of 144 (interquartile range 129–179) days after COVID-19 diagnosis. LA detection was positive only in three patients (5.9%) and mean level of vWF:Ag was 158.0% at the time of follow-up. No thrombotic event was observed during the follow-up phase (Fig. 1, Table 1). CONCLUSIONS: We showed disappearance of LA in a large majority of patients and a drastic decrease of vWF:Ag levels, clinically translated by the absence of thrombosis event during the follow-up. Our results suggest that endothelial dysfunction is transient in COVID-19 patients and therefore associated to a potential temporary and limited pathophysiological effect. |
format | Online Article Text |
id | pubmed-8710966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Published by Elsevier Masson SAS |
record_format | MEDLINE/PubMed |
spelling | pubmed-87109662021-12-28 Transient endothelial injury and release of lupus anticoagulant in COVID-19 Trimaille, A. Marchandot, B. Oulehri, W. Carmona, A. Vollmer, O. Poindron, V. Matsushita, K. Sattler, L. Grunebaum, L. Korganow, A. Schini-Kerth, V. Morel, O. Archives of Cardiovascular Diseases. Supplements 052 INTRODUCTION: Coronavirus disease 2019 (COVID-19) has been described as an endothelial disease associated with a procoagulant state and a high prevalence of lupus anticoagulant (LA). No study has so far evaluated the persistence of endothelial injury after recovery. PURPOSE: We report the results of a systematic biologic assessment more than 12 weeks after the acute phase of COVID-19. METHODS: Patients hospitalized for COVID-19 at Strasbourg university hospital, France, and tested positive for LA were included in the microparticles in COVID-19 (MICO) study. During the prospective follow-up, blood samples were obtained at least 12 weeks after COVID-19 diagnosis. RESULTS: Between March 3 and May 5, 2020, 56 COVID-19 patients with positive LA were included in the study. Five patients were excluded from the analysis because of direct oral anticoagulant treatment at the time of follow-up. A total of 51 patients were included in the final analysis. The mean age was 61 years. During the acute phase of COVID-19, 38 patients (74.5%) required mechanical ventilation, 10 patients (19.7%) presented a venous thrombotic event and mean von Willebrand factor antigen (vWF:Ag) level was 409.5%. Follow-up visit was performed at a median of 144 (interquartile range 129–179) days after COVID-19 diagnosis. LA detection was positive only in three patients (5.9%) and mean level of vWF:Ag was 158.0% at the time of follow-up. No thrombotic event was observed during the follow-up phase (Fig. 1, Table 1). CONCLUSIONS: We showed disappearance of LA in a large majority of patients and a drastic decrease of vWF:Ag levels, clinically translated by the absence of thrombosis event during the follow-up. Our results suggest that endothelial dysfunction is transient in COVID-19 patients and therefore associated to a potential temporary and limited pathophysiological effect. Published by Elsevier Masson SAS 2022-01 2021-12-27 /pmc/articles/PMC8710966/ http://dx.doi.org/10.1016/j.acvdsp.2021.10.002 Text en Copyright © 2021 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | 052 Trimaille, A. Marchandot, B. Oulehri, W. Carmona, A. Vollmer, O. Poindron, V. Matsushita, K. Sattler, L. Grunebaum, L. Korganow, A. Schini-Kerth, V. Morel, O. Transient endothelial injury and release of lupus anticoagulant in COVID-19 |
title | Transient endothelial injury and release of lupus anticoagulant in COVID-19 |
title_full | Transient endothelial injury and release of lupus anticoagulant in COVID-19 |
title_fullStr | Transient endothelial injury and release of lupus anticoagulant in COVID-19 |
title_full_unstemmed | Transient endothelial injury and release of lupus anticoagulant in COVID-19 |
title_short | Transient endothelial injury and release of lupus anticoagulant in COVID-19 |
title_sort | transient endothelial injury and release of lupus anticoagulant in covid-19 |
topic | 052 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710966/ http://dx.doi.org/10.1016/j.acvdsp.2021.10.002 |
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