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Endothelial dysfunction is the key of long COVID-19 symptoms: The results of TUN-EndCOV study

BACKGROUND: The COVID-19 disease is a multisystem disease due to in part to the vascular endothelium injury. Lasting effects and long-term sequalae could persist after the infection and may be due to persistent endothelial dysfunction. PURPOSE: Our study focused on the study of endothelial function...

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Autores principales: Charfeddine, S., Ibnhadjamor, H., Torjmen, S., Kraiem, S., Hammami, R., Bahloul, A., Kallel, N., Moussa, N., Touil, I., Milouchi, S., Elghoul, J., Meddeb, Z., Thabet, Y., Jdidi, J., Bouslema, K., Abdesselem, S., Abid, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS 2022
Materias:
317
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710970/
http://dx.doi.org/10.1016/j.acvdsp.2021.10.004
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author Charfeddine, S.
Ibnhadjamor, H.
Torjmen, S.
Kraiem, S.
Hammami, R.
Bahloul, A.
Kallel, N.
Moussa, N.
Touil, I.
Milouchi, S.
Elghoul, J.
Meddeb, Z.
Thabet, Y.
Jdidi, J.
Bouslema, K.
Abdesselem, S.
Abid, L.
author_facet Charfeddine, S.
Ibnhadjamor, H.
Torjmen, S.
Kraiem, S.
Hammami, R.
Bahloul, A.
Kallel, N.
Moussa, N.
Touil, I.
Milouchi, S.
Elghoul, J.
Meddeb, Z.
Thabet, Y.
Jdidi, J.
Bouslema, K.
Abdesselem, S.
Abid, L.
author_sort Charfeddine, S.
collection PubMed
description BACKGROUND: The COVID-19 disease is a multisystem disease due to in part to the vascular endothelium injury. Lasting effects and long-term sequalae could persist after the infection and may be due to persistent endothelial dysfunction. PURPOSE: Our study focused on the study of endothelial function measurement by digital thermal monitoring (DTM) of endothelial quality index with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long COVID-19 symptoms are due to endothelial dysfunction. METHODS: This is a prospective multicenter longitudinal observational cohort study. Endothelial function was evaluated with “E4-Diagnose” Polymath Tunisia based on the Endothelium Quality Index (EQI). A complete echocardiographic evaluation analysis was performed. Primary outcomes were defined as the occurrence of long COVID-19 symptoms in patients with endothelial dysfunction measured by EQI. RESULTS: A total of 798 patients were included in this study. Patients were included at an average time of 68.93 ± 43.1 days. The mean EQI was 2.02 ± 0.99 [0–5]. A total of 397 (49.7%) patients had poor or very poor EQI and 211 (26.4%) patients had very poor EQI. The median age was 49.94 ± 14.2 (18–80) years. A total of 618 patients (77.4%) had long COVID-19 symptoms. Patients with long COVID-19 symptoms had a reduced EQI (1.99 ± 0.97 vs. 2.09 ± 1.05, P = 0.24). Among long COVID-19 symptoms, fatigue was the most common symptom reported in 42.2%. Fatigue and chest pain were significantly associated to the endothelial dysfunction (P = 0.04 and 0.001 respectively). Patients with chest pain had significantly lower EQI (1.74 ± 1.0 vs. 2.09 ± 0.9, P ≤ 10(−3)) and LVGLS (−16.35 ± 3.0 vs. −17.16 ± 2.5, P = 0.04). CONCLUSION: Long COVID-19 symptoms specifically chest pain and fatigue are due to persistent poor endothelial quality index. These findings allow a better care of patients with long COVID-19 symptoms.
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spelling pubmed-87109702021-12-28 Endothelial dysfunction is the key of long COVID-19 symptoms: The results of TUN-EndCOV study Charfeddine, S. Ibnhadjamor, H. Torjmen, S. Kraiem, S. Hammami, R. Bahloul, A. Kallel, N. Moussa, N. Touil, I. Milouchi, S. Elghoul, J. Meddeb, Z. Thabet, Y. Jdidi, J. Bouslema, K. Abdesselem, S. Abid, L. Archives of Cardiovascular Diseases. Supplements 317 BACKGROUND: The COVID-19 disease is a multisystem disease due to in part to the vascular endothelium injury. Lasting effects and long-term sequalae could persist after the infection and may be due to persistent endothelial dysfunction. PURPOSE: Our study focused on the study of endothelial function measurement by digital thermal monitoring (DTM) of endothelial quality index with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long COVID-19 symptoms are due to endothelial dysfunction. METHODS: This is a prospective multicenter longitudinal observational cohort study. Endothelial function was evaluated with “E4-Diagnose” Polymath Tunisia based on the Endothelium Quality Index (EQI). A complete echocardiographic evaluation analysis was performed. Primary outcomes were defined as the occurrence of long COVID-19 symptoms in patients with endothelial dysfunction measured by EQI. RESULTS: A total of 798 patients were included in this study. Patients were included at an average time of 68.93 ± 43.1 days. The mean EQI was 2.02 ± 0.99 [0–5]. A total of 397 (49.7%) patients had poor or very poor EQI and 211 (26.4%) patients had very poor EQI. The median age was 49.94 ± 14.2 (18–80) years. A total of 618 patients (77.4%) had long COVID-19 symptoms. Patients with long COVID-19 symptoms had a reduced EQI (1.99 ± 0.97 vs. 2.09 ± 1.05, P = 0.24). Among long COVID-19 symptoms, fatigue was the most common symptom reported in 42.2%. Fatigue and chest pain were significantly associated to the endothelial dysfunction (P = 0.04 and 0.001 respectively). Patients with chest pain had significantly lower EQI (1.74 ± 1.0 vs. 2.09 ± 0.9, P ≤ 10(−3)) and LVGLS (−16.35 ± 3.0 vs. −17.16 ± 2.5, P = 0.04). CONCLUSION: Long COVID-19 symptoms specifically chest pain and fatigue are due to persistent poor endothelial quality index. These findings allow a better care of patients with long COVID-19 symptoms. Published by Elsevier Masson SAS 2022-01 2021-12-27 /pmc/articles/PMC8710970/ http://dx.doi.org/10.1016/j.acvdsp.2021.10.004 Text en Copyright © 2021 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle 317
Charfeddine, S.
Ibnhadjamor, H.
Torjmen, S.
Kraiem, S.
Hammami, R.
Bahloul, A.
Kallel, N.
Moussa, N.
Touil, I.
Milouchi, S.
Elghoul, J.
Meddeb, Z.
Thabet, Y.
Jdidi, J.
Bouslema, K.
Abdesselem, S.
Abid, L.
Endothelial dysfunction is the key of long COVID-19 symptoms: The results of TUN-EndCOV study
title Endothelial dysfunction is the key of long COVID-19 symptoms: The results of TUN-EndCOV study
title_full Endothelial dysfunction is the key of long COVID-19 symptoms: The results of TUN-EndCOV study
title_fullStr Endothelial dysfunction is the key of long COVID-19 symptoms: The results of TUN-EndCOV study
title_full_unstemmed Endothelial dysfunction is the key of long COVID-19 symptoms: The results of TUN-EndCOV study
title_short Endothelial dysfunction is the key of long COVID-19 symptoms: The results of TUN-EndCOV study
title_sort endothelial dysfunction is the key of long covid-19 symptoms: the results of tun-endcov study
topic 317
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710970/
http://dx.doi.org/10.1016/j.acvdsp.2021.10.004
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