A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury

Hepatotoxicity caused by an overdose of acetaminophen (APAP) is the leading reason for acute drug-related liver failure. Nuclear factor erythroid-2-related factor 2 (Nrf2) is a protein that helps to regulate redox homeostasis and coordinate stress responses via binding to the Kelch-like ECH-associat...

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Detalles Bibliográficos
Autores principales: Li, Guodong, Liu, Hao, Feng, Ruibing, Kang, Tian-Shu, Wang, Wanhe, Ko, Chung-Nga, Wong, Chun-Yuen, Ye, Min, Ma, Dik-Lung, Wan, Jian-Bo, Leung, Chung-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Articles from the Special Issue on Redox signaling in the pathogenesis and treatments of acute lung injury and beyond; Edited by Dr. Lin Mantell, Dr. Peter Vitiello and Dr. Eva Nozik
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710994/
https://www.ncbi.nlm.nih.gov/pubmed/34526248
http://dx.doi.org/10.1016/j.redox.2021.102129

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