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Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent

Risk factors and long-term consequences of COVID-19 infection are unclear but can be investigated with large-scale genomic data. To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N > 1,000,000). We show genetic correlation and putative causalit...

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Autores principales: Wendt, Frank R, De Lillo, Antonella, Pathak, Gita A, De Angelis, Flavio, Polimanti, Renato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711039/
https://www.ncbi.nlm.nih.gov/pubmed/34966408
http://dx.doi.org/10.3389/fgene.2021.765247
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author Wendt, Frank R
De Lillo, Antonella
Pathak, Gita A
De Angelis, Flavio
Polimanti, Renato
author_facet Wendt, Frank R
De Lillo, Antonella
Pathak, Gita A
De Angelis, Flavio
Polimanti, Renato
author_sort Wendt, Frank R
collection PubMed
description Risk factors and long-term consequences of COVID-19 infection are unclear but can be investigated with large-scale genomic data. To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N > 1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use (genetic causality proportion (gĉp) with severe respiratory COVID-19 = 0.576, p = 1.07 × 10(−5) and hospitalized COVID-19 = 0.713, p = 0.003), and alcohol drinking status (gĉp with severe respiratory COVID-19 = 0.633, p = 7.04 × 10(−5) and hospitalized COVID-19 = 0.848, p = 4.13 × 10(−13)). COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors and potential long-term health effects of severe response to infection.
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spelling pubmed-87110392021-12-28 Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent Wendt, Frank R De Lillo, Antonella Pathak, Gita A De Angelis, Flavio Polimanti, Renato Front Genet Genetics Risk factors and long-term consequences of COVID-19 infection are unclear but can be investigated with large-scale genomic data. To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N > 1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use (genetic causality proportion (gĉp) with severe respiratory COVID-19 = 0.576, p = 1.07 × 10(−5) and hospitalized COVID-19 = 0.713, p = 0.003), and alcohol drinking status (gĉp with severe respiratory COVID-19 = 0.633, p = 7.04 × 10(−5) and hospitalized COVID-19 = 0.848, p = 4.13 × 10(−13)). COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors and potential long-term health effects of severe response to infection. Frontiers Media S.A. 2021-12-13 /pmc/articles/PMC8711039/ /pubmed/34966408 http://dx.doi.org/10.3389/fgene.2021.765247 Text en Copyright © 2021 Wendt, De Lillo, Pathak, De Angelis and Polimanti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Wendt, Frank R
De Lillo, Antonella
Pathak, Gita A
De Angelis, Flavio
Polimanti, Renato
Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent
title Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent
title_full Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent
title_fullStr Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent
title_full_unstemmed Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent
title_short Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent
title_sort host genetic liability for severe covid-19 associates with alcohol drinking behavior and diabetic outcomes in participants of european descent
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711039/
https://www.ncbi.nlm.nih.gov/pubmed/34966408
http://dx.doi.org/10.3389/fgene.2021.765247
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