The Molecular Roles and Clinical Implications of Non-Coding RNAs in Gastric Cancer

Gastric cancer (GC) is one of the most common malignancies in the world. It is also the fifth most common cancer in China. In recent years, a large number of studies have proved that non-coding RNAs (ncRNAs) can regulate cell proliferation, invasion, metastasis, apoptosis, and angiogenesis. NcRNAs a...

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Autores principales: Yue, Yanping, Lin, Xinrong, Qiu, Xinyue, Yang, Lei, Wang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711095/
https://www.ncbi.nlm.nih.gov/pubmed/34966746
http://dx.doi.org/10.3389/fcell.2021.802745
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author Yue, Yanping
Lin, Xinrong
Qiu, Xinyue
Yang, Lei
Wang, Rui
author_facet Yue, Yanping
Lin, Xinrong
Qiu, Xinyue
Yang, Lei
Wang, Rui
author_sort Yue, Yanping
collection PubMed
description Gastric cancer (GC) is one of the most common malignancies in the world. It is also the fifth most common cancer in China. In recent years, a large number of studies have proved that non-coding RNAs (ncRNAs) can regulate cell proliferation, invasion, metastasis, apoptosis, and angiogenesis. NcRNAs also influence the therapeutic resistance of gastric cancer. NcRNAs mainly consist of miRNAs, lncRNAs and circRNAs. In this paper, we summarized ncRNAs as biomarkers and therapeutic targets for gastric cancer, and also reviewed their role in clinical trials and diagnosis. We sum up different ncRNAs and related moleculars and signaling pathway in gastric cancer, like Bcl-2, PTEN, Wnt signaling. In addition, the potential clinical application of ncRNAs in overcoming chemotherapy and radiotherapy resistance in GC in the future were also focused on.
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spelling pubmed-87110952021-12-28 The Molecular Roles and Clinical Implications of Non-Coding RNAs in Gastric Cancer Yue, Yanping Lin, Xinrong Qiu, Xinyue Yang, Lei Wang, Rui Front Cell Dev Biol Cell and Developmental Biology Gastric cancer (GC) is one of the most common malignancies in the world. It is also the fifth most common cancer in China. In recent years, a large number of studies have proved that non-coding RNAs (ncRNAs) can regulate cell proliferation, invasion, metastasis, apoptosis, and angiogenesis. NcRNAs also influence the therapeutic resistance of gastric cancer. NcRNAs mainly consist of miRNAs, lncRNAs and circRNAs. In this paper, we summarized ncRNAs as biomarkers and therapeutic targets for gastric cancer, and also reviewed their role in clinical trials and diagnosis. We sum up different ncRNAs and related moleculars and signaling pathway in gastric cancer, like Bcl-2, PTEN, Wnt signaling. In addition, the potential clinical application of ncRNAs in overcoming chemotherapy and radiotherapy resistance in GC in the future were also focused on. Frontiers Media S.A. 2021-12-13 /pmc/articles/PMC8711095/ /pubmed/34966746 http://dx.doi.org/10.3389/fcell.2021.802745 Text en Copyright © 2021 Yue, Lin, Qiu, Yang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yue, Yanping
Lin, Xinrong
Qiu, Xinyue
Yang, Lei
Wang, Rui
The Molecular Roles and Clinical Implications of Non-Coding RNAs in Gastric Cancer
title The Molecular Roles and Clinical Implications of Non-Coding RNAs in Gastric Cancer
title_full The Molecular Roles and Clinical Implications of Non-Coding RNAs in Gastric Cancer
title_fullStr The Molecular Roles and Clinical Implications of Non-Coding RNAs in Gastric Cancer
title_full_unstemmed The Molecular Roles and Clinical Implications of Non-Coding RNAs in Gastric Cancer
title_short The Molecular Roles and Clinical Implications of Non-Coding RNAs in Gastric Cancer
title_sort molecular roles and clinical implications of non-coding rnas in gastric cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711095/
https://www.ncbi.nlm.nih.gov/pubmed/34966746
http://dx.doi.org/10.3389/fcell.2021.802745
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