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Highly Efficient Cyclization Approach of Propargylated Peptides via Gold(I)-Mediated Sequential C–N, C–O, and C–C Bond Formation

[Image: see text] A rapid and efficient cyclization of unprotected N-propargylated peptides using the Au(I) organometallic complex is reported. The method relies on the activation of the propargyl functionality using gold(I) to produce a new linkage with the N-terminus amine at the cyclization site....

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Detalles Bibliográficos
Autores principales:	Vanjari, Rajeshwer, Eid, Emad, Vamisetti, Ganga B., Mandal, Shaswati, Brik, Ashraf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711126/ https://www.ncbi.nlm.nih.gov/pubmed/34966846 http://dx.doi.org/10.1021/acscentsci.1c00969

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