Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

Glioblastoma (GBM) is highly resistant to chemotherapies, immune-based therapies, and targeted inhibitors. To identify novel drug targets, we screened orthotopically implanted, patient-derived glioblastoma sphere-forming cells using an RNAi library to probe essential tumor cell metabolic programs. T...

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Detalles Bibliográficos
Autores principales: Puca, Francesca, Yu, Fei, Bartolacci, Caterina, Pettazzoni, Piergiorgio, Carugo, Alessandro, Huang-Hobbs, Emmet, Liu, Jintan, Zanca, Ciro, Carbone, Federica, Del Poggetto, Edoardo, Gumin, Joy, Dasgupta, Pushan, Seth, Sahil, Srinivasan, Sanjana, Lang, Frederick F., Sulman, Erik P., Lorenzi, Philip L., Tan, Lin, Shan, Mengrou, Tolstyka, Zachary P., Kachman, Maureen, Zhang, Li, Gao, Sisi, Deem, Angela K., Genovese, Giannicola, Scaglioni, Pier Paolo, Lyssiotis, Costas A., Viale, Andrea, Draetta, Giulio F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711129/
https://www.ncbi.nlm.nih.gov/pubmed/34039636
http://dx.doi.org/10.1158/2159-8290.CD-20-1437

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