Virucidal activity of SARS-CoV-2 rapid antigen extraction buffers

Since diagnostic sampling material must be considered as infectious, we evaluated whether extraction buffers of SARS-CoV-2 rapid antigen test kits may inactivate SARS-CoV-2. Of concern, seven of nine tested buffers lacked potent virucidal activity. To reduce risk of infection during assay performanc...

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Autores principales: Conzelmann, Carina, Weil, Tatjana, Olari, Lia-Raluca, Gilg, Andrea, Rauch, Lena, Albers, Dan P.J., Groß, Rüdiger, Müller, Janis A., Münch, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711173/
https://www.ncbi.nlm.nih.gov/pubmed/34995991
http://dx.doi.org/10.1016/j.jcv.2021.105062
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author Conzelmann, Carina
Weil, Tatjana
Olari, Lia-Raluca
Gilg, Andrea
Rauch, Lena
Albers, Dan P.J.
Groß, Rüdiger
Müller, Janis A.
Münch, Jan
author_facet Conzelmann, Carina
Weil, Tatjana
Olari, Lia-Raluca
Gilg, Andrea
Rauch, Lena
Albers, Dan P.J.
Groß, Rüdiger
Müller, Janis A.
Münch, Jan
author_sort Conzelmann, Carina
collection PubMed
description Since diagnostic sampling material must be considered as infectious, we evaluated whether extraction buffers of SARS-CoV-2 rapid antigen test kits may inactivate SARS-CoV-2. Of concern, seven of nine tested buffers lacked potent virucidal activity. To reduce risk of infection during assay performance, virucidal antigen extraction buffers that efficiently inactivate virus should replace the extraction buffers in these commercially available point-of-care devices.
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spelling pubmed-87111732021-12-28 Virucidal activity of SARS-CoV-2 rapid antigen extraction buffers Conzelmann, Carina Weil, Tatjana Olari, Lia-Raluca Gilg, Andrea Rauch, Lena Albers, Dan P.J. Groß, Rüdiger Müller, Janis A. Münch, Jan J Clin Virol Article Since diagnostic sampling material must be considered as infectious, we evaluated whether extraction buffers of SARS-CoV-2 rapid antigen test kits may inactivate SARS-CoV-2. Of concern, seven of nine tested buffers lacked potent virucidal activity. To reduce risk of infection during assay performance, virucidal antigen extraction buffers that efficiently inactivate virus should replace the extraction buffers in these commercially available point-of-care devices. The Author(s). Published by Elsevier B.V. 2022-02 2021-12-27 /pmc/articles/PMC8711173/ /pubmed/34995991 http://dx.doi.org/10.1016/j.jcv.2021.105062 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Conzelmann, Carina
Weil, Tatjana
Olari, Lia-Raluca
Gilg, Andrea
Rauch, Lena
Albers, Dan P.J.
Groß, Rüdiger
Müller, Janis A.
Münch, Jan
Virucidal activity of SARS-CoV-2 rapid antigen extraction buffers
title Virucidal activity of SARS-CoV-2 rapid antigen extraction buffers
title_full Virucidal activity of SARS-CoV-2 rapid antigen extraction buffers
title_fullStr Virucidal activity of SARS-CoV-2 rapid antigen extraction buffers
title_full_unstemmed Virucidal activity of SARS-CoV-2 rapid antigen extraction buffers
title_short Virucidal activity of SARS-CoV-2 rapid antigen extraction buffers
title_sort virucidal activity of sars-cov-2 rapid antigen extraction buffers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711173/
https://www.ncbi.nlm.nih.gov/pubmed/34995991
http://dx.doi.org/10.1016/j.jcv.2021.105062
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