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Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes
BACKGROUND: To evaluate the radial peripapillary capillary (RPC) density in the fellow eyes of unilateral retinal vein occlusion (RVO) patients using optical coherence tomography angiography (OCTA), and further analyze the correlation between RPC density and peripapillary retinal nerve fiber layer (...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711181/ https://www.ncbi.nlm.nih.gov/pubmed/34961508 http://dx.doi.org/10.1186/s12886-021-02192-y |
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author | Fan, Lingling Zhu, Yazhou Sun, Xiaomei Yu, Jinguo Yan, Hua |
author_facet | Fan, Lingling Zhu, Yazhou Sun, Xiaomei Yu, Jinguo Yan, Hua |
author_sort | Fan, Lingling |
collection | PubMed |
description | BACKGROUND: To evaluate the radial peripapillary capillary (RPC) density in the fellow eyes of unilateral retinal vein occlusion (RVO) patients using optical coherence tomography angiography (OCTA), and further analyze the correlation between RPC density and peripapillary retinal nerve fiber layer (RNFL) thickness. METHODS: Seventy-eight unilateral RVO patients and 70 normal controls were included in the study. OCTA was conducted with the 4.5 × 4.5-mm scan pattern centered on the optic nerve head, and the RPC density and peripapillary RNFL thickness were quantified. RESULTS: The peripapillary RNFL in the RVO fellow eyes was significantly thinner than in normal controls in the average, inferior-hemisphere, inferior quadrant, and temporal quadrant (P < 0.05, respectively). The RPC density in the fellow eyes was also significantly lower in the average, inferior-hemisphere, nasal quadrant, and temporal quadrant ((P < 0.05, respectively). There were no significant differences in RNFL thickness and RPC density between branch RVO fellow eyes and central RVO fellow eyes. Pearson’s correlation analysis showed significant positive correlations between the RPC density and RNFL thickness in all measurements (P < 0.001, respectively). CONCLUSIONS: The regional RPC density was reduced in the RVO fellow eyes, which might contribute to peripapillary RNFL thinning in the corresponding region, suggesting the influence of systemic risk factors on RVO. OCTA may offer new insights into the pathophysiology of RVO. |
format | Online Article Text |
id | pubmed-8711181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-87111812022-01-05 Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes Fan, Lingling Zhu, Yazhou Sun, Xiaomei Yu, Jinguo Yan, Hua BMC Ophthalmol Research BACKGROUND: To evaluate the radial peripapillary capillary (RPC) density in the fellow eyes of unilateral retinal vein occlusion (RVO) patients using optical coherence tomography angiography (OCTA), and further analyze the correlation between RPC density and peripapillary retinal nerve fiber layer (RNFL) thickness. METHODS: Seventy-eight unilateral RVO patients and 70 normal controls were included in the study. OCTA was conducted with the 4.5 × 4.5-mm scan pattern centered on the optic nerve head, and the RPC density and peripapillary RNFL thickness were quantified. RESULTS: The peripapillary RNFL in the RVO fellow eyes was significantly thinner than in normal controls in the average, inferior-hemisphere, inferior quadrant, and temporal quadrant (P < 0.05, respectively). The RPC density in the fellow eyes was also significantly lower in the average, inferior-hemisphere, nasal quadrant, and temporal quadrant ((P < 0.05, respectively). There were no significant differences in RNFL thickness and RPC density between branch RVO fellow eyes and central RVO fellow eyes. Pearson’s correlation analysis showed significant positive correlations between the RPC density and RNFL thickness in all measurements (P < 0.001, respectively). CONCLUSIONS: The regional RPC density was reduced in the RVO fellow eyes, which might contribute to peripapillary RNFL thinning in the corresponding region, suggesting the influence of systemic risk factors on RVO. OCTA may offer new insights into the pathophysiology of RVO. BioMed Central 2021-12-27 /pmc/articles/PMC8711181/ /pubmed/34961508 http://dx.doi.org/10.1186/s12886-021-02192-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Fan, Lingling Zhu, Yazhou Sun, Xiaomei Yu, Jinguo Yan, Hua Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes |
title | Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes |
title_full | Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes |
title_fullStr | Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes |
title_full_unstemmed | Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes |
title_short | Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes |
title_sort | patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711181/ https://www.ncbi.nlm.nih.gov/pubmed/34961508 http://dx.doi.org/10.1186/s12886-021-02192-y |
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