Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological pro...

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Autores principales: Chapoval, Svetlana P., Keegan, Achsah D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711287/
https://www.ncbi.nlm.nih.gov/pubmed/34961486
http://dx.doi.org/10.1186/s10020-021-00423-y
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author Chapoval, Svetlana P.
Keegan, Achsah D.
author_facet Chapoval, Svetlana P.
Keegan, Achsah D.
author_sort Chapoval, Svetlana P.
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike–NRP1 interaction to combat virus infectivity and severe disease manifestations.
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spelling pubmed-87112872021-12-28 Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection Chapoval, Svetlana P. Keegan, Achsah D. Mol Med Review Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike–NRP1 interaction to combat virus infectivity and severe disease manifestations. BioMed Central 2021-12-27 /pmc/articles/PMC8711287/ /pubmed/34961486 http://dx.doi.org/10.1186/s10020-021-00423-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Chapoval, Svetlana P.
Keegan, Achsah D.
Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
title Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
title_full Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
title_fullStr Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
title_full_unstemmed Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
title_short Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
title_sort perspectives and potential approaches for targeting neuropilin 1 in sars-cov-2 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711287/
https://www.ncbi.nlm.nih.gov/pubmed/34961486
http://dx.doi.org/10.1186/s10020-021-00423-y
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