Rational Designed Hybrid Peptides Show up to a 6-Fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides Measured by BioSAXS

Antimicrobial peptides (AMPs) are a promising class of compounds being developed against multi-drug resistant bacteria. Hybridization has been reported to increase antimicrobial activity. Here, two proline-rich peptides (consP1: VRKPPYLPRPRPRPL-CONH(2) and Bac5-v291: RWRRPIRRRPIRPPFWR-CONH(2)) were...

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Detalles Bibliográficos
Autores principales: Hilpert, Kai, Gani, Jurnorain, Rumancev, Christoph, Simpson, Nathan, Lopez-Perez, Paula Matilde, Garamus, Vasil M., von Gundlach, Andreas Robert, Markov, Petar, Scocchi, Marco, Mikut, Ralf, Rosenhahn, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711299/
https://www.ncbi.nlm.nih.gov/pubmed/34966279
http://dx.doi.org/10.3389/fphar.2021.769739

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