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Simultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole‑Induced Drug–Drug Interaction

BACKGROUND: Loratadine (LTD) is a Biopharmaceutical Classification System II basic drug with pH-sensitive aqueous solubility and dissolution is a speed-limiting step of its absorption. The drug dissolution and the gastrointestinal tract pH conditions are likely to influence the in vivo pharmacokinet...

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Detalles Bibliográficos
Autores principales:	Zhang, Yu, Zhang, Jiaming, Xu, Qiuchi, Wang, Yimeng, Wu, Wenying, Wang, Weiping, Li, Xiaoting, Zhang, Tianhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711562/ https://www.ncbi.nlm.nih.gov/pubmed/34992347 http://dx.doi.org/10.2147/DDDT.S328106

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