Cargando…

Using drug scheduling to manage adverse events associated with hedgehog pathway inhibitors for basal cell carcinoma

Basal cell carcinoma (BCC) is the most common malignancy and form of skin cancer worldwide; advanced BCC, either as locally advanced BCC (laBCC) or metastatic BCC (mBCC), can cause substantial tissue invasion and morbidity. Until the recent availability of the hedgehog pathway inhibitors (HHIs) soni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lear, John T., Dummer, Reinhard, Guminski, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711575/ https://www.ncbi.nlm.nih.gov/pubmed/34966484 http://dx.doi.org/10.18632/oncotarget.28145

Ejemplares similares

Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma
por: Lacouture, Mario E., et al.
Publicado: (2016)

Effects of Sonidegib Following Dose Reduction and Treatment Interruption in Patients with Advanced Basal Cell Carcinoma During 42-Month BOLT Trial
por: Lewis, Karl, et al.
Publicado: (2021)

Basal Cell Carcinoma and Hedgehog Pathway Inhibitors: Focus on Immune Response
por: Gambini, Donatella, et al.
Publicado: (2022)

Hedgehog Pathway Inhibitors: Clinical Implications and Resistance in the Treatment of Basal Cell Carcinoma
por: Habashy, Suzanne, et al.
Publicado: (2021)

Effective treatment of locally advanced periocular basal cell carcinoma with oral hedgehog pathway inhibitor?
por: Hou, Xiaoyi, et al.
Publicado: (2020)

Expression of Glioma-associated oncogene homolog 1 as biomarker with sonidegib in advanced basal cell carcinoma
por: Dummer, Reinhard, et al.
Publicado: (2020)

Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors
por: Fecher, Leslie A, et al.
Publicado: (2015)

Key Clinical Adverse Events in Patients with Advanced Basal Cell Carcinoma Treated with Sonidegib or Vismodegib: A Post Hoc Analysis
por: Gutzmer, Ralf, et al.
Publicado: (2021)

Update on Hedgehog Pathway Inhibitor Therapy for Patients with Basal Cell Naevus Syndrome or High-frequency Basal Cell Carcinoma
por: VERKOUTEREN, Babette J. A., et al.
Publicado: (2022)

Vismodegib: First-in-Class Hedgehog Pathway Inhibitor for Metastatic or Locally Advanced Basal Cell Carcinoma
por: Nix, Nancy M., et al.
Publicado: (2014)

Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence
por: Tay, Evelyn Yu-Xin, et al.
Publicado: (2018)

Treatment of Advanced Basal Cell Carcinoma with Hedgehog Pathway Inhibitors: A Multidisciplinary Expert Meeting
por: De Giorgi, Vincenzo, et al.
Publicado: (2021)

Spontaneous resolution of advanced basal cell carcinoma after short-pulse treatment with hedgehog pathway inhibitor
por: Jacobsen, Audrey A., et al.
Publicado: (2016)

Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib
por: Hehlgans, Stephanie, et al.
Publicado: (2018)

Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma
por: Cucchi, Danilo, et al.
Publicado: (2012)

Non-canonical hedgehog pathway activation by MKL1/SRF promotes drug-resistance in basal cell carcinomas
por: Whitson, Ramon J., et al.
Publicado: (2018)

New dosing schedules of dasatinib for CML and adverse event management
por: Wong, Siu-Fun
Publicado: (2009)

Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva
por: CELEBI, ALI RIZA CENK, et al.
Publicado: (2016)

Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
por: Takada, Tomoaki
Publicado: (2021)

Expression of Hedgehog Signaling Pathway Proteins in Basal Cell Carcinoma: Clinicopathologic Study
por: Deng, Li-Jia, et al.
Publicado: (2022)

Efficacy and Safety of Sonidegib in Adult Patients with Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome): Results from a Phase 2, Double-Blind, Randomized Trial
por: Lear, John T, et al.
Publicado: (2020)

Qualitative Patient Interviews to Characterize the Human Burden of Advanced Basal Cell Carcinoma Following Hedgehog Pathway Inhibitor Treatment
por: Konidaris, Gerasimos, et al.
Publicado: (2023)

An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma
por: Gruber, Wolfgang, et al.
Publicado: (2014)

Immunoprevention of Basal Cell Carcinomas with Recombinant Hedgehog-interacting Protein
por: Vogt, Annika, et al.
Publicado: (2004)

Hedgehog pathway as a drug target: Smoothened inhibitors in development
por: Lin, Tara L, et al.
Publicado: (2012)

Switching Hedgehog inhibitors and other strategies to address resistance when treating advanced basal cell carcinoma
por: Doan, Hung Q., et al.
Publicado: (2021)

The Role of Actin in Muscle Spasms in a Case Series of Patients with Advanced Basal Cell Carcinoma Treated with a Hedgehog Pathway Inhibitor
por: Teh, Natalie, et al.
Publicado: (2020)

Swiss Recommendations for Cutaneous Basal Cell Carcinoma
por: Ramelyte, Egle, et al.
Publicado: (2022)

Focus on Basal Cell Carcinoma
por: Samarasinghe, Venura, et al.
Publicado: (2011)

Treatment of periocular advanced basal cell carcinoma with Hedgehog pathway inhibitors: A single-center study and a new dedicated therapeutic protocol
por: De Giorgi, Vincenzo, et al.
Publicado: (2021)

Reinduction of Hedgehog Inhibitors after Checkpoint Inhibition in Advanced Basal Cell Carcinoma: A Series of 12 Patients
por: DeTemple, Viola K., et al.
Publicado: (2022)

Downregulation of the Sonic Hedgehog/Gli pathway transcriptional target Neogenin-1 is associated with basal cell carcinoma aggressiveness
por: Casas, Bárbara S., et al.
Publicado: (2017)

Novel Approaches in Non-Melanoma Skin Cancers—A Focus on Hedgehog Pathway in Basal Cell Carcinoma (BCC)
por: Chmiel, Paulina, et al.
Publicado: (2022)

Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
por: Kim, Hye Sung, et al.
Publicado: (2019)

Modulation of Hedgehog Signaling for the Treatment of Basal Cell Carcinoma and the Development of Preclinical Models
por: Dukes, Meghan W., et al.
Publicado: (2022)

Systemic hedgehog inhibitors to treat locally advanced basal cell carcinomas of the head–neck region: A retrospective study
por: Villani, Alessia, et al.
Publicado: (2021)

Patients with advanced basal cell carcinomas in treatment with sonic hedgehog inhibitors during the coronavirus disease 2019 (COVID-19) period: Management and adherence to treatment
por: Villani, Alessia, et al.
Publicado: (2020)

Drugging Hedgehog: signaling the pathway to translation
por: Carney, Tom J, et al.
Publicado: (2013)

Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance
por: Nguyen, Ngoc Minh, et al.
Publicado: (2022)

Long‐term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30‐month analysis of the randomized phase 2 BOLT study
por: Lear, J.T., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_79faps35uicqicuoal2tl47jt8