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Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)

Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to ischemic strokes, which constitutes the majority of strokes. Ischemic strokes induce brain infarcts, along with cerebral...

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Autores principales: Zhao, Yunfei, Zhang, Xiaojing, Chen, Xinye, Wei, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711586/
https://www.ncbi.nlm.nih.gov/pubmed/34878154
http://dx.doi.org/10.3892/ijmm.2021.5070
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author Zhao, Yunfei
Zhang, Xiaojing
Chen, Xinye
Wei, Yun
author_facet Zhao, Yunfei
Zhang, Xiaojing
Chen, Xinye
Wei, Yun
author_sort Zhao, Yunfei
collection PubMed
description Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to ischemic strokes, which constitutes the majority of strokes. Ischemic strokes induce brain infarcts, along with cerebral tissue death and focal neuronal damage. The infarct size and neurological severity after ischemic stroke episodes depends on the time period since occurrence, the severity of ischemia, systemic blood pressure, vein systems and location of infarcts, amongst others. Ischemic stroke is a complex disease, and neuronal injuries after ischemic strokes have been the focus of current studies. The present review will provide a basic pathological background of ischemic stroke and cerebral infarcts. Moreover, the major mechanisms underlying ischemic stroke and neuronal injuries are summarized. This review will also briefly summarize some representative clinical trials and up-to-date treatments that have been applied to stroke and brain infarcts.
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spelling pubmed-87115862022-01-12 Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review) Zhao, Yunfei Zhang, Xiaojing Chen, Xinye Wei, Yun Int J Mol Med Articles Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to ischemic strokes, which constitutes the majority of strokes. Ischemic strokes induce brain infarcts, along with cerebral tissue death and focal neuronal damage. The infarct size and neurological severity after ischemic stroke episodes depends on the time period since occurrence, the severity of ischemia, systemic blood pressure, vein systems and location of infarcts, amongst others. Ischemic stroke is a complex disease, and neuronal injuries after ischemic strokes have been the focus of current studies. The present review will provide a basic pathological background of ischemic stroke and cerebral infarcts. Moreover, the major mechanisms underlying ischemic stroke and neuronal injuries are summarized. This review will also briefly summarize some representative clinical trials and up-to-date treatments that have been applied to stroke and brain infarcts. D.A. Spandidos 2022-02 2021-12-08 /pmc/articles/PMC8711586/ /pubmed/34878154 http://dx.doi.org/10.3892/ijmm.2021.5070 Text en Copyright: © Zhao et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhao, Yunfei
Zhang, Xiaojing
Chen, Xinye
Wei, Yun
Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)
title Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)
title_full Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)
title_fullStr Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)
title_full_unstemmed Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)
title_short Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)
title_sort neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711586/
https://www.ncbi.nlm.nih.gov/pubmed/34878154
http://dx.doi.org/10.3892/ijmm.2021.5070
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