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Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)
Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to ischemic strokes, which constitutes the majority of strokes. Ischemic strokes induce brain infarcts, along with cerebral...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711586/ https://www.ncbi.nlm.nih.gov/pubmed/34878154 http://dx.doi.org/10.3892/ijmm.2021.5070 |
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author | Zhao, Yunfei Zhang, Xiaojing Chen, Xinye Wei, Yun |
author_facet | Zhao, Yunfei Zhang, Xiaojing Chen, Xinye Wei, Yun |
author_sort | Zhao, Yunfei |
collection | PubMed |
description | Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to ischemic strokes, which constitutes the majority of strokes. Ischemic strokes induce brain infarcts, along with cerebral tissue death and focal neuronal damage. The infarct size and neurological severity after ischemic stroke episodes depends on the time period since occurrence, the severity of ischemia, systemic blood pressure, vein systems and location of infarcts, amongst others. Ischemic stroke is a complex disease, and neuronal injuries after ischemic strokes have been the focus of current studies. The present review will provide a basic pathological background of ischemic stroke and cerebral infarcts. Moreover, the major mechanisms underlying ischemic stroke and neuronal injuries are summarized. This review will also briefly summarize some representative clinical trials and up-to-date treatments that have been applied to stroke and brain infarcts. |
format | Online Article Text |
id | pubmed-8711586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-87115862022-01-12 Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review) Zhao, Yunfei Zhang, Xiaojing Chen, Xinye Wei, Yun Int J Mol Med Articles Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to ischemic strokes, which constitutes the majority of strokes. Ischemic strokes induce brain infarcts, along with cerebral tissue death and focal neuronal damage. The infarct size and neurological severity after ischemic stroke episodes depends on the time period since occurrence, the severity of ischemia, systemic blood pressure, vein systems and location of infarcts, amongst others. Ischemic stroke is a complex disease, and neuronal injuries after ischemic strokes have been the focus of current studies. The present review will provide a basic pathological background of ischemic stroke and cerebral infarcts. Moreover, the major mechanisms underlying ischemic stroke and neuronal injuries are summarized. This review will also briefly summarize some representative clinical trials and up-to-date treatments that have been applied to stroke and brain infarcts. D.A. Spandidos 2022-02 2021-12-08 /pmc/articles/PMC8711586/ /pubmed/34878154 http://dx.doi.org/10.3892/ijmm.2021.5070 Text en Copyright: © Zhao et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Zhao, Yunfei Zhang, Xiaojing Chen, Xinye Wei, Yun Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review) |
title | Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review) |
title_full | Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review) |
title_fullStr | Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review) |
title_full_unstemmed | Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review) |
title_short | Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review) |
title_sort | neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment (review) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711586/ https://www.ncbi.nlm.nih.gov/pubmed/34878154 http://dx.doi.org/10.3892/ijmm.2021.5070 |
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