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Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy

Post-stroke Epilepsy (PSE) is one of the most common forms of acquired epilepsy, especially in the elderly population. As people get increasingly older, the number of stroke patients is expected to rise and concomitantly the number of people with PSE. Although many patients are affected by post-isch...

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Autores principales: Tröscher, Anna Regina, Gruber, Joachim, Wagner, Judith N., Böhm, Vincent, Wahl, Anna-Sophia, von Oertzen, Tim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711648/
https://www.ncbi.nlm.nih.gov/pubmed/34966269
http://dx.doi.org/10.3389/fnagi.2021.781174
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author Tröscher, Anna Regina
Gruber, Joachim
Wagner, Judith N.
Böhm, Vincent
Wahl, Anna-Sophia
von Oertzen, Tim J.
author_facet Tröscher, Anna Regina
Gruber, Joachim
Wagner, Judith N.
Böhm, Vincent
Wahl, Anna-Sophia
von Oertzen, Tim J.
author_sort Tröscher, Anna Regina
collection PubMed
description Post-stroke Epilepsy (PSE) is one of the most common forms of acquired epilepsy, especially in the elderly population. As people get increasingly older, the number of stroke patients is expected to rise and concomitantly the number of people with PSE. Although many patients are affected by post-ischemic epileptogenesis, not much is known about the underlying pathomechanisms resulting in the development of chronic seizures. A common hypothesis is that persistent neuroinflammation and glial scar formation cause aberrant neuronal firing. Here, we summarize the clinical features of PSE and describe in detail the inflammatory changes after an ischemic stroke as well as the chronic changes reported in epilepsy. Moreover, we discuss alterations and disturbances in blood-brain-barrier leakage, astrogliosis, and extracellular matrix changes in both, stroke and epilepsy. In the end, we provide an overview of commonalities of inflammatory reactions and cellular processes in the post-ischemic environment and epileptic brain and discuss how these research questions should be addressed in the future.
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spelling pubmed-87116482021-12-28 Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy Tröscher, Anna Regina Gruber, Joachim Wagner, Judith N. Böhm, Vincent Wahl, Anna-Sophia von Oertzen, Tim J. Front Aging Neurosci Aging Neuroscience Post-stroke Epilepsy (PSE) is one of the most common forms of acquired epilepsy, especially in the elderly population. As people get increasingly older, the number of stroke patients is expected to rise and concomitantly the number of people with PSE. Although many patients are affected by post-ischemic epileptogenesis, not much is known about the underlying pathomechanisms resulting in the development of chronic seizures. A common hypothesis is that persistent neuroinflammation and glial scar formation cause aberrant neuronal firing. Here, we summarize the clinical features of PSE and describe in detail the inflammatory changes after an ischemic stroke as well as the chronic changes reported in epilepsy. Moreover, we discuss alterations and disturbances in blood-brain-barrier leakage, astrogliosis, and extracellular matrix changes in both, stroke and epilepsy. In the end, we provide an overview of commonalities of inflammatory reactions and cellular processes in the post-ischemic environment and epileptic brain and discuss how these research questions should be addressed in the future. Frontiers Media S.A. 2021-12-13 /pmc/articles/PMC8711648/ /pubmed/34966269 http://dx.doi.org/10.3389/fnagi.2021.781174 Text en Copyright © 2021 Tröscher, Gruber, Wagner, Böhm, Wahl and von Oertzen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Tröscher, Anna Regina
Gruber, Joachim
Wagner, Judith N.
Böhm, Vincent
Wahl, Anna-Sophia
von Oertzen, Tim J.
Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy
title Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy
title_full Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy
title_fullStr Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy
title_full_unstemmed Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy
title_short Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy
title_sort inflammation mediated epileptogenesis as possible mechanism underlying ischemic post-stroke epilepsy
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711648/
https://www.ncbi.nlm.nih.gov/pubmed/34966269
http://dx.doi.org/10.3389/fnagi.2021.781174
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