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The role of maternal serum catestatin in the evaluation of preeclampsia and fetal cardiac functions
OBJECTIVE: To compare the maternal serum catestatin (CST) levels in pregnant women with preeclampsia (PE) and with normal blood pressure and evaluate the relationship between the maternal serum CST levels and fetal cardiac functions. MATERIALS AND METHODS: This cross-sectional study was conducted on...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711669/ https://www.ncbi.nlm.nih.gov/pubmed/34955005 http://dx.doi.org/10.4274/tjod.galenos.2021.34946 |
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author | Özalp, Miraç Yaman, Hüseyin Demir, Ömer Aytekin Garip, Sümeyye Aran, Turhan Osmanağaoğlu, Mehmet Armağan |
author_facet | Özalp, Miraç Yaman, Hüseyin Demir, Ömer Aytekin Garip, Sümeyye Aran, Turhan Osmanağaoğlu, Mehmet Armağan |
author_sort | Özalp, Miraç |
collection | PubMed |
description | OBJECTIVE: To compare the maternal serum catestatin (CST) levels in pregnant women with preeclampsia (PE) and with normal blood pressure and evaluate the relationship between the maternal serum CST levels and fetal cardiac functions. MATERIALS AND METHODS: This cross-sectional study was conducted on 27 women with early-onset PE (EOPE), 28 women with late-onset PE (LOPE), and 28 healthy pregnant women. Maternal serum CST levels were measured using the enzyme-linked immunosorbent assay kits. Fetal cardiac functions were evaluated using the cardiac Doppler. RESULTS: Maternal serum CST levels were lower in the EOPE group; however, no statistically significant difference was found between the groups. Compared with the other two groups, a statistically significant difference was found in the fetal E/A ratio and myocardial performance index (MPI) values of the EOPE group (p=0.013, p=0.002, p=0.005, p<0.001, respectively). The fetal E/A ratio was positively correlated with the maternal serum CST levels in both the PE and control groups (p<0.001, p<0.001). The fetal isovolumetric relaxation time and MPI values were negatively correlated with maternal serum CST levels in both the PE and control groups (p<0.001, p=0.001, p<0.001, and p=0.002, respectively). CONCLUSION: Lower CST levels are associated with fetal cardiovascular dysfunction, thus CST can be a critical biochemical marker in fetal cardiac function evaluation. |
format | Online Article Text |
id | pubmed-8711669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-87116692022-01-07 The role of maternal serum catestatin in the evaluation of preeclampsia and fetal cardiac functions Özalp, Miraç Yaman, Hüseyin Demir, Ömer Aytekin Garip, Sümeyye Aran, Turhan Osmanağaoğlu, Mehmet Armağan Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: To compare the maternal serum catestatin (CST) levels in pregnant women with preeclampsia (PE) and with normal blood pressure and evaluate the relationship between the maternal serum CST levels and fetal cardiac functions. MATERIALS AND METHODS: This cross-sectional study was conducted on 27 women with early-onset PE (EOPE), 28 women with late-onset PE (LOPE), and 28 healthy pregnant women. Maternal serum CST levels were measured using the enzyme-linked immunosorbent assay kits. Fetal cardiac functions were evaluated using the cardiac Doppler. RESULTS: Maternal serum CST levels were lower in the EOPE group; however, no statistically significant difference was found between the groups. Compared with the other two groups, a statistically significant difference was found in the fetal E/A ratio and myocardial performance index (MPI) values of the EOPE group (p=0.013, p=0.002, p=0.005, p<0.001, respectively). The fetal E/A ratio was positively correlated with the maternal serum CST levels in both the PE and control groups (p<0.001, p<0.001). The fetal isovolumetric relaxation time and MPI values were negatively correlated with maternal serum CST levels in both the PE and control groups (p<0.001, p=0.001, p<0.001, and p=0.002, respectively). CONCLUSION: Lower CST levels are associated with fetal cardiovascular dysfunction, thus CST can be a critical biochemical marker in fetal cardiac function evaluation. Galenos Publishing 2021-12 2021-12-24 /pmc/articles/PMC8711669/ /pubmed/34955005 http://dx.doi.org/10.4274/tjod.galenos.2021.34946 Text en ©Copyright 2021 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation Özalp, Miraç Yaman, Hüseyin Demir, Ömer Aytekin Garip, Sümeyye Aran, Turhan Osmanağaoğlu, Mehmet Armağan The role of maternal serum catestatin in the evaluation of preeclampsia and fetal cardiac functions |
title | The role of maternal serum catestatin in the evaluation of preeclampsia and fetal cardiac functions |
title_full | The role of maternal serum catestatin in the evaluation of preeclampsia and fetal cardiac functions |
title_fullStr | The role of maternal serum catestatin in the evaluation of preeclampsia and fetal cardiac functions |
title_full_unstemmed | The role of maternal serum catestatin in the evaluation of preeclampsia and fetal cardiac functions |
title_short | The role of maternal serum catestatin in the evaluation of preeclampsia and fetal cardiac functions |
title_sort | role of maternal serum catestatin in the evaluation of preeclampsia and fetal cardiac functions |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711669/ https://www.ncbi.nlm.nih.gov/pubmed/34955005 http://dx.doi.org/10.4274/tjod.galenos.2021.34946 |
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