Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity

The autophagy-lysosomal pathway is impaired in many neurodegenerative diseases characterized by protein aggregation, but the link between aggregation and lysosomal dysfunction remains poorly understood. Here, we combine cryo-electron tomography, proteomics, and cell biology studies to investigate th...

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Detalles Bibliográficos
Autores principales: Riera-Tur, Irene, Schäfer, Tillman, Hornburg, Daniel, Mishra, Archana, da Silva Padilha, Miguel, Fernández-Mosquera, Lorena, Feigenbutz, Dennis, Auer, Patrick, Mann, Matthias, Baumeister, Wolfgang, Klein, Rüdiger, Meissner, Felix, Raimundo, Nuno, Fernández-Busnadiego, Rubén, Dudanova, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711852/
https://www.ncbi.nlm.nih.gov/pubmed/34933920
http://dx.doi.org/10.26508/lsa.202101185

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