Response to Hydroxyurea in a Patient With Sickle Cell Hepatopathy: A Case Report

Sickle cell hepatopathy is an underreported entity lacking clear management guidelines. This case highlights the potential role of hydroxyurea (HU) in improving the hepatic dysfunction seen among patients with sickle cell disease (SCD). We herein present the clinical course of a patient prior to and...

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Detalles Bibliográficos
Autores principales: Safhi, Maha A, Baghdadi, Rana M, Al-Marzouki, Adel F, Al-Sayes, Fatin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Hematology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712197/
https://www.ncbi.nlm.nih.gov/pubmed/34976545
http://dx.doi.org/10.7759/cureus.20649
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author Safhi, Maha A
Baghdadi, Rana M
Al-Marzouki, Adel F
Al-Sayes, Fatin
author_facet Safhi, Maha A
Baghdadi, Rana M
Al-Marzouki, Adel F
Al-Sayes, Fatin
author_sort Safhi, Maha A
collection PubMed
description Sickle cell hepatopathy is an underreported entity lacking clear management guidelines. This case highlights the potential role of hydroxyurea (HU) in improving the hepatic dysfunction seen among patients with sickle cell disease (SCD). We herein present the clinical course of a patient prior to and after the initiation of hydroxyurea with an emphasis on long-term outcomes and the patterns of liver injury over a 15-year time course.
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spelling pubmed-87121972021-12-30 Response to Hydroxyurea in a Patient With Sickle Cell Hepatopathy: A Case Report Safhi, Maha A Baghdadi, Rana M Al-Marzouki, Adel F Al-Sayes, Fatin Cureus Hematology Sickle cell hepatopathy is an underreported entity lacking clear management guidelines. This case highlights the potential role of hydroxyurea (HU) in improving the hepatic dysfunction seen among patients with sickle cell disease (SCD). We herein present the clinical course of a patient prior to and after the initiation of hydroxyurea with an emphasis on long-term outcomes and the patterns of liver injury over a 15-year time course. Cureus 2021-12-23 /pmc/articles/PMC8712197/ /pubmed/34976545 http://dx.doi.org/10.7759/cureus.20649 Text en Copyright © 2021, Safhi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Hematology
Safhi, Maha A
Baghdadi, Rana M
Al-Marzouki, Adel F
Al-Sayes, Fatin
Response to Hydroxyurea in a Patient With Sickle Cell Hepatopathy: A Case Report
title Response to Hydroxyurea in a Patient With Sickle Cell Hepatopathy: A Case Report
title_full Response to Hydroxyurea in a Patient With Sickle Cell Hepatopathy: A Case Report
title_fullStr Response to Hydroxyurea in a Patient With Sickle Cell Hepatopathy: A Case Report
title_full_unstemmed Response to Hydroxyurea in a Patient With Sickle Cell Hepatopathy: A Case Report
title_short Response to Hydroxyurea in a Patient With Sickle Cell Hepatopathy: A Case Report
title_sort response to hydroxyurea in a patient with sickle cell hepatopathy: a case report
topic Hematology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712197/
https://www.ncbi.nlm.nih.gov/pubmed/34976545
http://dx.doi.org/10.7759/cureus.20649
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AT almarzoukiadelf responsetohydroxyureainapatientwithsicklecellhepatopathyacasereport
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