Cargando…

Cellular sources of TSPO expression in healthy and diseased brain

The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer mitochondrial membrane. TSPO binding, as measured with positron emission tomography (PET), is considered an in vivo marker of neuroinflammation. Indeed, TSPO expression is altered in neurodegenerative, neuroinf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nutma, Erik, Ceyzériat, Kelly, Amor, Sandra, Tsartsalis, Stergios, Millet, Philippe, Owen, David R., Papadopoulos, Vassilios, Tournier, Benjamin B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712293/ https://www.ncbi.nlm.nih.gov/pubmed/33433698 http://dx.doi.org/10.1007/s00259-020-05166-2

Ejemplares similares

In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease
por: Tournier, Benjamin B., et al.
Publicado: (2020)

Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease
por: Tournier, Benjamin B., et al.
Publicado: (2020)

Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer’s disease
por: Gloria, Yesica, et al.
Publicado: (2021)

Amyloid and Tau Induce Cell Death Independently of TSPO Polymerization and Density Changes
por: Tournier, Benjamin B., et al.
Publicado: (2021)

Alterations in dopamine system and in its connectivity with serotonin in a rat model of Alzheimer’s disease
por: Ceyzériat, Kelly, et al.
Publicado: (2021)

The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects
por: Tournier, Benjamin B., et al.
Publicado: (2022)

18 kDa Translocator Protein TSPO Is a Mediator of Astrocyte Reactivity
por: Tournier, Benjamin B., et al.
Publicado: (2023)

Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum
por: Ceyzériat, Kelly, et al.
Publicado: (2023)

In vivo absolute quantification of striatal and extrastriatal D(2/3) receptors with [(123)I]epidepride SPECT
por: Tsartsalis, Stergios, et al.
Publicado: (2020)

Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats
por: Ceyzériat, Kelly, et al.
Publicado: (2022)

Activated microglia do not increase 18 kDa translocator protein (TSPO) expression in the multiple sclerosis brain
por: Nutma, Erik, et al.
Publicado: (2021)

Effect of 5-HT2A receptor antagonism on levels of D2/3 receptor occupancy and adverse behavioral side-effects induced by haloperidol: a SPECT imaging study in the rat
por: Tsartsalis, Stergios, et al.
Publicado: (2021)

Dopamine and Neuroinflammation in Schizophrenia – Interpreting the Findings from Translocator Protein (18kDa) PET Imaging
por: Iliopoulou, Sotiria Maria, et al.
Publicado: (2021)

Dynamic image denoising for voxel-wise quantification with Statistical Parametric Mapping in molecular neuroimaging
por: Tsartsalis, Stergios, et al.
Publicado: (2018)

Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain
por: Betlazar, Calina, et al.
Publicado: (2018)

Amhr2-Cre–Mediated Global Tspo Knockout
por: Fan, Jinjiang, et al.
Publicado: (2020)

SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model
por: Tsartsalis, Stergios, et al.
Publicado: (2015)

Mitochondrial TSPO Deficiency Triggers Retrograde Signaling in MA-10 Mouse Tumor Leydig Cells
por: Fan, Jinjiang, et al.
Publicado: (2020)

Imaging immunological processes from blood to brain in amyotrophic lateral sclerosis
por: Amor, Sandra, et al.
Publicado: (2021)

TSPO expression in brain tumours: is TSPO a target for brain tumour imaging?
por: Roncaroli, Federico, et al.
Publicado: (2016)

Bacterial Ortholog of Mammalian Translocator Protein (TSPO) with Virulence Regulating Activity
por: Chapalain, Annelise, et al.
Publicado: (2009)

Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO
por: Iatmanen-Harbi, Soria, et al.
Publicado: (2019)

Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas
por: Leneveu-Jenvrin, Charlène, et al.
Publicado: (2014)

Dopamine D(2/3) Receptor Availabilities and Evoked Dopamine Release in Striatum Differentially Predict Impulsivity and Novelty Preference in Roman High- and Low-Avoidance Rats
por: Bellés, Lidia, et al.
Publicado: (2020)

SUN-042 Loss of the 18-Kda Translocator Protein Tspo Destabilizes Cholesterol Homeostasis in a Hepatic Steatosis Cell Model
por: Li, Yuchang, et al.
Publicado: (2019)

TSPO imaging in animal models of brain diseases
por: Van Camp, Nadja, et al.
Publicado: (2021)

TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis
por: Owen, David R., et al.
Publicado: (2017)

Identifying improved TSPO PET imaging probes through biomathematics: The impact of multiple TSPO binding sites in vivo
por: Guo, Qi, et al.
Publicado: (2012)

Resolving the cellular specificity of TSPO imaging in a rat model of peripherally-induced neuroinflammation
por: Vicente-Rodríguez, Marta, et al.
Publicado: (2021)

Reduction of Traumatic Brain Damage by Tspo Ligand Etifoxine
por: Shehadeh, Mona, et al.
Publicado: (2019)

Biomarkers to Evaluate Androgen Deprivation Therapy for Prostate Cancer and Risk of Alzheimer’s Disease and Neurodegeneration: Old Drugs, New Concerns
por: Achard, Vérane, et al.
Publicado: (2021)

Autophagy in white matter disorders of the CNS: mechanisms and therapeutic opportunities
por: Nutma, Erik, et al.
Publicado: (2020)

Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies
por: Grimm, Amandine, et al.
Publicado: (2019)

Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System
por: Nutma, Erik, et al.
Publicado: (2020)

TSPO imaging in parkinsonian disorders
por: Gerhard, Alexander
Publicado: (2016)

PET imaging shows no changes in TSPO brain density after IFN-α immune challenge in healthy human volunteers
por: Nettis, M. A., et al.
Publicado: (2020)

A TSPO ligand attenuates brain injury after intracerebral hemorrhage
por: Li, Minshu, et al.
Publicado: (2017)

Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain
por: Wimberley, Catriona, et al.
Publicado: (2021)

An Updated View of Translocator Protein (TSPO)
por: Denora, Nunzio, et al.
Publicado: (2017)

The role of TSPO PET in assessing neuroinflammation
por: Crawshaw, Ania A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_37itt1q6qc502ej5eauri5qdrh