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FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis

PURPOSE: This study assesses the potential for vascular-metabolic imaging with FluoroDeoxyGlucose (FDG)–Positron Emission Tomography/Computed Tomography (PET/CT) perfusion to provide markers of prognosis specific to the site and stage of colorectal cancer. METHODS: This prospective observational stu...

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Autores principales: Chen, Shih-hsin, Miles, Kenneth, Taylor, Stuart A., Ganeshan, Balaji, Rodriquez, Manuel, Fraioli, Francesco, Wan, Simon, Afaq, Asim, Shortman, Robert, Walls, Darren, Hoy, Luke, Endozo, Raymond, Bhargava, Aman, Hanson, Matthew, Huang, Joseph, Raouf, Sherif, Francis, Daren, Siddiqi, Shahab, Arulampalam, Tan, Sizer, Bruce, Machesney, Michael, Reay-Jones, Nicholas, Dindyal, Sanjay, Ng, Tony, Groves, Ashley M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712298/
https://www.ncbi.nlm.nih.gov/pubmed/33837843
http://dx.doi.org/10.1007/s00259-021-05318-y
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author Chen, Shih-hsin
Miles, Kenneth
Taylor, Stuart A.
Ganeshan, Balaji
Rodriquez, Manuel
Fraioli, Francesco
Wan, Simon
Afaq, Asim
Shortman, Robert
Walls, Darren
Hoy, Luke
Endozo, Raymond
Bhargava, Aman
Hanson, Matthew
Huang, Joseph
Raouf, Sherif
Francis, Daren
Siddiqi, Shahab
Arulampalam, Tan
Sizer, Bruce
Machesney, Michael
Reay-Jones, Nicholas
Dindyal, Sanjay
Ng, Tony
Groves, Ashley M
author_facet Chen, Shih-hsin
Miles, Kenneth
Taylor, Stuart A.
Ganeshan, Balaji
Rodriquez, Manuel
Fraioli, Francesco
Wan, Simon
Afaq, Asim
Shortman, Robert
Walls, Darren
Hoy, Luke
Endozo, Raymond
Bhargava, Aman
Hanson, Matthew
Huang, Joseph
Raouf, Sherif
Francis, Daren
Siddiqi, Shahab
Arulampalam, Tan
Sizer, Bruce
Machesney, Michael
Reay-Jones, Nicholas
Dindyal, Sanjay
Ng, Tony
Groves, Ashley M
author_sort Chen, Shih-hsin
collection PubMed
description PURPOSE: This study assesses the potential for vascular-metabolic imaging with FluoroDeoxyGlucose (FDG)–Positron Emission Tomography/Computed Tomography (PET/CT) perfusion to provide markers of prognosis specific to the site and stage of colorectal cancer. METHODS: This prospective observational study comprised of participants with suspected colorectal cancer categorized as either (a) non-metastatic colon cancer (M0colon), (b) non-metastatic rectal cancer (M0rectum), or (c) metastatic colorectal cancer (M+). Combined FDG-PET/CT perfusion imaging was successfully performed in 286 participants (184 males, 102 females, age: 69.60 ± 10 years) deriving vascular and metabolic imaging parameters. Vascular and metabolic imaging parameters alone and in combination were investigated with respect to overall survival. RESULTS: A vascular-metabolic signature that was significantly associated with poorer survival was identified for each patient group: M0colon – high Total Lesion Glycolysis (TLG) with increased Permeability Surface Area Product/Blood Flow (PS/BF), Hazard Ratio (HR) 3.472 (95% CI: 1.441–8.333), p = 0.006; M0rectum – high Metabolic Tumour Volume (MTV) with increased PS/BF, HR 4.567 (95% CI: 1.901–10.970), p = 0.001; M+ participants, high MTV with longer Time To Peak (TTP) enhancement, HR 2.421 (95% CI: 1.162–5.045), p = 0.018. In participants with stage 2 colon cancer as well as those with stage 3 rectal cancer, the vascular-metabolic signature could stratify the prognosis of these participants. CONCLUSION: Vascular and metabolic imaging using FDG-PET/CT can be used to synergise prognostic markers. The hazard ratios suggest that the technique may have clinical utility.
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spelling pubmed-87122982022-01-11 FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis Chen, Shih-hsin Miles, Kenneth Taylor, Stuart A. Ganeshan, Balaji Rodriquez, Manuel Fraioli, Francesco Wan, Simon Afaq, Asim Shortman, Robert Walls, Darren Hoy, Luke Endozo, Raymond Bhargava, Aman Hanson, Matthew Huang, Joseph Raouf, Sherif Francis, Daren Siddiqi, Shahab Arulampalam, Tan Sizer, Bruce Machesney, Michael Reay-Jones, Nicholas Dindyal, Sanjay Ng, Tony Groves, Ashley M Eur J Nucl Med Mol Imaging Original Article PURPOSE: This study assesses the potential for vascular-metabolic imaging with FluoroDeoxyGlucose (FDG)–Positron Emission Tomography/Computed Tomography (PET/CT) perfusion to provide markers of prognosis specific to the site and stage of colorectal cancer. METHODS: This prospective observational study comprised of participants with suspected colorectal cancer categorized as either (a) non-metastatic colon cancer (M0colon), (b) non-metastatic rectal cancer (M0rectum), or (c) metastatic colorectal cancer (M+). Combined FDG-PET/CT perfusion imaging was successfully performed in 286 participants (184 males, 102 females, age: 69.60 ± 10 years) deriving vascular and metabolic imaging parameters. Vascular and metabolic imaging parameters alone and in combination were investigated with respect to overall survival. RESULTS: A vascular-metabolic signature that was significantly associated with poorer survival was identified for each patient group: M0colon – high Total Lesion Glycolysis (TLG) with increased Permeability Surface Area Product/Blood Flow (PS/BF), Hazard Ratio (HR) 3.472 (95% CI: 1.441–8.333), p = 0.006; M0rectum – high Metabolic Tumour Volume (MTV) with increased PS/BF, HR 4.567 (95% CI: 1.901–10.970), p = 0.001; M+ participants, high MTV with longer Time To Peak (TTP) enhancement, HR 2.421 (95% CI: 1.162–5.045), p = 0.018. In participants with stage 2 colon cancer as well as those with stage 3 rectal cancer, the vascular-metabolic signature could stratify the prognosis of these participants. CONCLUSION: Vascular and metabolic imaging using FDG-PET/CT can be used to synergise prognostic markers. The hazard ratios suggest that the technique may have clinical utility. Springer Berlin Heidelberg 2021-04-10 2021 /pmc/articles/PMC8712298/ /pubmed/33837843 http://dx.doi.org/10.1007/s00259-021-05318-y Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Chen, Shih-hsin
Miles, Kenneth
Taylor, Stuart A.
Ganeshan, Balaji
Rodriquez, Manuel
Fraioli, Francesco
Wan, Simon
Afaq, Asim
Shortman, Robert
Walls, Darren
Hoy, Luke
Endozo, Raymond
Bhargava, Aman
Hanson, Matthew
Huang, Joseph
Raouf, Sherif
Francis, Daren
Siddiqi, Shahab
Arulampalam, Tan
Sizer, Bruce
Machesney, Michael
Reay-Jones, Nicholas
Dindyal, Sanjay
Ng, Tony
Groves, Ashley M
FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
title FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
title_full FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
title_fullStr FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
title_full_unstemmed FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
title_short FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
title_sort fdg-pet/ct in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712298/
https://www.ncbi.nlm.nih.gov/pubmed/33837843
http://dx.doi.org/10.1007/s00259-021-05318-y
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